By George Rylance, David R. Harvey and JacoB.V. Aranda (Eds.)
A piece on neonates and the ways that medicines impact them. one of the issues coated are the placental move of substances, maternal analgesia and anaesthesia and their impression at the baby, the remedy of cardiac problems within the neonate and the absorption of gear during the dermis
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Extra info for Neonatal Clinical Pharmacology and Therapeutics
And Dring, L. G. (1972) The rate of procaine hydrolysis in serum of normal subjects and diseased patients. Clinical Pharmacology and Therapeutics, 13, 279-284 33. Aranda, J. , MacLeod, S. , Renton, K. , et al. (1974) Hepatic microsomal drug oxidation and electron transport in newborn infants. Journal of Pediatrics, 85, 534-542 34. Morselli, P. , Franco-Morselli, R. and Bossi, L. (1980) Clinical pharmacokinetics in newborns and infants. Clinical Pharmacokinetics, 5, 485-527 35. Aranda, J. , Sitar, D.
The fetus is more susceptible than the mother to the anticoagulant effect of warfarin,34 since though it crosses the placenta, Vitamin K-dependent clotting factors do not, while production by the fetal liver is deficient. The effect of warfarin can therefore be reversed in the baby only by administering fresh frozen plasma. Heparin on the other hand is a polar ionized mucopolysaccharide and neither standard heparin, of molecular weight 20 000-40 000, nor low molecular weight 35 heparin (3000-5000) cross the placenta in detectable amounts.
Journal of Pediatrics, 84, 265-269 54. Gould, T. and Roberts, R. J. (1979) Therapeutic problems arising from the use of the intravenous route for drug administration. Journal of Pediatrics, 95, 465-469 55. Feigin, R. , Moss, K. S. and Shackelford, P. G. (1973) Antibiotic stability in solutions used for intravenous nutrition and fluid therapy. Pediatrics, 51, 1016-1026 56. Schuetz, D. H. and King, J. C. (1978) Compatibility and stability of electrolytes, vitamins and antibiotics in combination with 8% amino-acid solution.
Neonatal Clinical Pharmacology and Therapeutics by George Rylance, David R. Harvey and JacoB.V. Aranda (Eds.)