By Joan B. Tarloff, Lawrence H. Lash
The kidney performs an essential function in convinced endocrine services. Abnormalities attributable to poisonous chemical compounds or different interventions may have profound results on those features and for this reason, on overall services. up-to-date to mirror the most recent study within the box, Toxicology of the Kidney, 3rd variation specializes in the correlation among the anatomy, biochemistry, and body structure of the kidney. The textual content seeks to provide an explanation for how this correlation is said to techniques of medical nephrotoxicity, and renal failure in people and the way animal types can be utilized to appreciate the mechanisms of human renal illness.
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Extra resources for Toxicology of the Kidney, 3rd Edition (Target Organ Toxicology Series)
A type III epithelium is illustrated, which exhibits prominent apical plasma membrane microprojections. , 1992). , 1995). , 1993). , 1996 Urea permeability is heterogeneous in different tDL subsegments. , 1984, 1988; Kokko, 1972; Stoner and Roch-Ramel, 1979). In rat types I and II tDL, urea permeability is higher than in the other species but is still relatively low (Morgan and Berliner, 1968). Urea permeability is higher in hamster and chinchilla type III tDL (Chou and Knepper, 1993; Imai et al.
However, a causal link has not been established between organic anion secretion and cytochrome P450-mediated arachidonic acid metabolism (Badr, 1995). Anatomy and physiology of the kidneys 23 Sodium-dependent secondary active transporters also mediate organic cation secretion. Organic cations generally enter the cell by a facilitated transport pathway located in the basolateral plasma membrane and are secreted across the apical plasma membrane into the tubule lumen by an amiloride-inhibitable Na+−H+ antiporter coupled to a protonorganic cation exchanger.
1985). ACKNOWLEDGMENTS This work was supported by National Institutes of Health grants R01-DK41707, R01DK63657, and P01-DK50268. REFERENCES Abramow M, and Orci L (1980) On the “tightness” of the rabbit descending limb of the loop of Henle-physiological and morphological evidence. Int J Biochem 12:23–27. Alper SL, Natale J, Gluck S, Lodish HF, and Brown D (1989) Subtypes of intercalated cells in rat kidney collecting duct defined by antibodies against erythroid band 3 and renal vacuolar H+ATPase.
Toxicology of the Kidney, 3rd Edition (Target Organ Toxicology Series) by Joan B. Tarloff, Lawrence H. Lash