By Christopher P. Holstege, Matthew P. Borloz, John P. Benner NREMT-P, David T. Lawrence DO, Nathan P. Charlton MD
Written essentially for 3rd and fourth 12 months scientific scholars, Toxicology bear in mind is an entire, concise evaluate of scientific toxicology. The ebook is written within the rapid-fire question-and-answer layout of the bear in mind sequence, with the query showing at the left part of the web page and the reply showing at the correct. Mnemonics and reference charts extra reduction in fast evaluation. significant sections hide review of the poisoned sufferer, drugs, medicines of abuse, environmental and commercial pollutants, heavy metals, insecticides, chemical brokers of terrorism, typical pollution, cures, and visible prognosis in clinical toxicology.
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IV diphenhydramine, corticosteroids, and SQ epinephrine should be considered in appropriate cases, but these agents may not significantly alter clinical progression. What are the predominant signs and symptoms of ACE inhibitor overdose? Acute ACE inhibitor overdose does not often result in significant toxicity. Hypotension and, occasionally, bradycardia may occur. Hyperkalemia may be seen, even in therapeutic doses. What treatments are recommended for overdose of ACE inhibitors? 1. Activated charcoal, if given within 1 hr of overdose 2.
These drugs cause release of norepinephrine from the presynaptic terminal, resulting in a sympathomimetic syndrome. What hyperthermic syndrome can result from MAOI use? Serotonin syndrome Which medications increase this risk? Concurrent use of any medication that ↑ serotonin levels, including SSRIs, LSD, dextromethorphan, meperidine, and tramadol What are the clinical signs of serotonin syndrome? AMS, hyperthermia, autonomic instability, hyperreflexia, and clonus What is the primary treatment for serotonin syndrome?
CNS toxicity – seizures and/or AMS Which CAs have been reported to cause isolated status epilepticus with no QRS widening or anticholinergic signs? Amoxapine and maprotiline What considerations should be made regarding the CAtoxic patient experiencing seizures? 1. Treat seizures with IV benzodiazepines. 2. Avoid phenytoin as it may exacerbate cardiac Naϩ channel blockade. 3. Monitor for acidosis and hyperthermia. 4. Avoid paralytic agents, as they can mask seizure activity. How should the CA overdose be treated?
Toxicology Recall by Christopher P. Holstege, Matthew P. Borloz, John P. Benner NREMT-P, David T. Lawrence DO, Nathan P. Charlton MD