By Robert Krieger
ISBN-10: 0123743672
ISBN-13: 9780123743671
The Handbook of Pesticide Toxicology is a finished, two-volume reference advisor to the homes, results, and legislation of insecticides that gives the newest and so much whole info to researchers investigating the environmental, agricultural, veterinary, and human-health affects of pesticide use. Written through overseas specialists from academia, govt, and the non-public area, the guide of Pesticide Toxicology is an in-depth exam of serious matters on the topic of the necessity for, use of, and nature of chemical substances utilized in sleek pest administration. This up-to-date 3rd version includes at the book's culture of serving because the definitive reference on pesticide toxicology and recognizies the seminal contribution of Wayland J. Hayes, Jr., co-Editor of the 1st edition.
Feature: provides a accomplished examine all facets of pesticide toxicology in a single reference paintings.
Benefit: Saves researchers time in speedy gaining access to the very newest definitive information on toxicity of particular insecticides in place of looking through hundreds of thousands of magazine articles.
Feature: transparent exposition of chance id and dose reaction relationships in each one bankruptcy that includes pesticide brokers and actions
Benefit: Connects the experimental laboratory effects to real-life purposes in human healthiness, animal future health and the environment.
Feature: All significant periods of pesticide considered.
Benefit: offers relevance to a much broader number of researchers who're undertaking comparative paintings in insecticides or their health and wellbeing impacts.
Feature: various routes of publicity seriously evaluated.
Benefit: Connects the loop among publicity and destructive impacts to those that are studying the impacts of insecticides on people or wildlife.
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Extra resources for Handbook of Pesticide Toxicology, Volumes 1-2 (3rd Edition)
Sample text
Gaddum stressed the importance of converting mea surements in such a way that the results may be subjected to statistical evaluation. In addition to logarithmic conver sion of each variable for this purpose, he suggested that a positive or negative constant might be added to each vari able prior to its logarithmic conversion. The logprobit conversion has great value for purposes of description and statistical analysis. However, in spite of its great practical value, the basic assumption that the rela tionship of variables is perfectly lognormal cannot be con sidered proved, because the upper and lower extremities of the curve have not been studied experimentally to a suffi cient degree.
Some compounds are inherently likely to produce chronic effects, which is largely the same as saying that their effects are highly irreversible. In some instances, a single dose not sufficient to produce any immediate effect or perhaps no detectable immediate effect, eventually leads to chronic illness. It is important to realize that there is no necessary rela tionship between the number of doses and the chronicity of illness. If a material capable of producing chronic effects is administered repeatedly, the chance that chronic effects will occur is increased, and the chance that only acute poisoning will occur is decreased.
G. CO-induced asphyxi ation) depending on the time to effect (death). Similarly problematic is the counting of dead animals. g. 14 days). For example, rats exposed to NO2 acutely by inhalation die of either spasm of the larynx or edema of the lungs. Spasm of the larynx and lung edema have very obviously different mechanisms of action and as such are part of different dose and time responses. Therefore, they will distort the c t concept if lumped together. The biggest problem with the ED 50 and LD 50 studies is that for the most part they were and are not conducted under conditions of toxicodynamic and/or toxicokinetic steady state and, therefore, almost all studies measure not only toxicity, but toxicity and recovery at the same time.
Handbook of Pesticide Toxicology, Volumes 1-2 (3rd Edition) by Robert Krieger
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