By Patricia Frank
This re-creation of a widely-read and highly-acclaimed e-book broadens the scope of its predecessors from a heavy concentrate on business chemical substances as toxicants to incorporate medicinal drugs, meals ingredients, cosmetics and different varieties of compounds that individuals are uncovered to day-by-day. additionally new to the 3rd variation are more recent issues-of-the-day such as nanoparticulate toxicants, moment hand smoke, meals infection, lead in toys, and others. As such, the e-book offers the fundamentals of toxicology in easy-to-understand language in addition to a fuller figuring out of the day-by-day insults to which bodies are subjected.Content:
Chapter 1 What are chemical substances? (pages 1–17):
Chapter 2 What damage do chemical compounds reason? (pages 19–29):
Chapter three what's Toxicology? (pages 31–45):
Chapter four What elements impression the poisonous results of chemical compounds? (pages 47–79):
Chapter five How is Toxicology Studied? (pages 81–101):
Chapter 6 basic Toxicology (pages 103–127):
Chapter 7 Mutagenesis and Carcinogenesis (pages 129–152):
Chapter eight Developmental and Reproductive Toxicity (pages 153–161):
Chapter nine Case experiences in Toxicology (pages 163–190):
Chapter 10 Epidemiology (pages 191–210):
Chapter eleven The examine of hazard (pages 211–228):
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Extra info for The Dose Makes the Poison: A Plain-Language Guide to Toxicology, Third Edition
Indd 39 12/16/2010 7:54:28 PM 40 WHAT IS TOXICOLOGY? the modern FDA required evidence of the safety of cosmetics and medical devices, and by 1949, it gained power to require safety testing of drugs and developed the first set of standards for animal testing of drugs. Along with the evolution of our protection of food and the environment, FDA evolved in its protection of our drugs and medical devices with the development and passage of the Good Laboratory Practices Act in 1979. The GPs were put into place to govern all aspects of pharmaceutical development; they include the Good Laboratory Practices (GLPs), the Good Manufacturing Practices (GMPs), and the Good Clinical Practices (GCPs), which set standards for performing toxicology studies, manufacturing drugs and medical devices, and testing those products in humans.
In all of his studies of the occupations, he followed his subjects into the mines, factories, and cesspools to see and experience the conditions under which they labored. indd 33 12/16/2010 7:54:28 PM 34 WHAT IS TOXICOLOGY? is no substitute for firsthand knowledge and that occupational exposures could be involved in the causation of disease. Ramazzini is remembered today by the medical profession for his wise counsel that, in addition to the usual questions, doctors should inquire into the occupations of their patients.
The demand for more applications of nonpersistent pesticides may result in an increased environmental burden of degradation products since the degradents themselves may be toxic. By forcing a ban on persistent pesticides, environmentalists may very well have created a much larger environmental problem than the problem they perceived as requiring the ban. Time will tell, if someone asks the right questions. Time has already told us that the switch from persistent to nonpersistent pesticides has greatly increased the number of acute poisonings among farm workers.
The Dose Makes the Poison: A Plain-Language Guide to Toxicology, Third Edition by Patricia Frank