By J. Turton, J. Hooson
ISBN-10: 0203481925
ISBN-13: 9780203481929
ISBN-10: 0203790162
ISBN-13: 9780203790168
ISBN-10: 0748401563
ISBN-13: 9780748401567
ISBN-10: 0748401571
ISBN-13: 9780748401574
The key organs of the physique are ambitions for chemically-induced results in animals and people. This e-book stories the mechanisms of those poisonous results and the structure/functional adjustments which take place within the goal organ tissues for this reason.
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Additional info for Target Organ Pathology - A Basic Text
Sample text
For example, discs of film of a certain size induced tumours, whereas the same weight of powdered material did not. Despite these arguments, potential carcinogenicity can be indicated by the appearance of sarcomas following subcutaneous injection. For instance, if a high incidence of tumours at the treatment site occurs within a few months of treatment, the substance is likely to have carcinogenic potential. This is particularly the case if a high incidence of tumours also occurs at other sites.
D) Detail of the same carcinoma showing disorganized structure, cells showing squamous differentiation (S) and neighbouring cells in mitosis. mainly confined to papillomas, squamous cell carcinomas and fibrosarcomas. Basal cell carcinomas, sebaceous adenomas, fibromas, schwannomas, lymphomas and mast cell tumours occur rarely. Mammary tumours may be seen, depending on where the skin is taken from; these are quite common in certain strains of mice and are known to have a viral aetiology. The incidence of spontaneous skin tumours (excluding mammary tumours) in a group of 50 untreated mice kept for 2 years is generally less than 4 per cent.
The flattening of thin paraffin sections of skin can be a problem because of folding, but this can be circumvented by floating the sections on cold water on a slide before transferring to the hot bath. Orientation of the skin section is most easily achieved by mounting the skin on a rectangular piece of card for fixation, the long axis coinciding with the direction of hair growth. For most purposes, sections parallel to the direction of hair growth are preferable, but in some circumstances, sections at right angles to this may be required.
Target Organ Pathology - A Basic Text by J. Turton, J. Hooson
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