By James L. Schardein (Author), Orest T. Macina (Author)
Offering the 1st database of its type, this specific reference illustrates the relationships among the chemistry and developmental toxicity of a few vital prescribed drugs and commercial toxicants. Human Developmental Toxicants comprises up to date and concise details at the chemical buildings, houses, and organic actions for fifty recognized brokers that adversely impact prenatal and postnatal human improvement when it comes to development, viability, constitution, and serve as. This e-book offers info linking chemical and structural homes of particular toxicants as they relate to poisonous results, dosage, timing, and direction of publicity. concentrating on one compound in line with bankruptcy, the e-book additionally contains linked organic info from animals for every agent coated. An accompanying CD summarizes all the facts mentioned within the textual content inside an digital database. additionally, the CD comprises 3-dimensional constitution representations and forty nine calculated physicochemical and topological parameters of the chosen molecules. this knowledge comes in handy for development constitution job courting (SAR) versions linking the chemical homes with saw human developmental toxicity. As scientists proceed to discover how chemical compounds adjust human improvement, Human Developmental Toxicants includes the mandatory info to extra determine which chemical houses are accountable for opposed results. This reference offers toxicologists, teratologists, chemists and different scientists with the newest info and data had to practice probability checks, are expecting chemical substances which can produce developmental toxicity, and control damaging publicity.
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Extra info for Human Developmental Toxicants: Aspects of Toxicology and Chemistry
57–58. fm Page 23 Friday, June 30, 2006 3:08 PM 5 Chlorambucil Chemical name: 4-[Bis(2-chloroethyl)amino]benzene butanoic acid Alternate name: Chloraminophene CAS #: 305-03-3 SMILES: c1(ccc(cc1)CCCC(O)=O)N(CCCl)CCCl HO O Cl N Cl INTRODUCTION Chlorambucil is an alkylating antineoplastic agent used therapeutically in the management of chronic lymphocytic leukemia, Hodgkin’s and non-Hodgkin’s lymphoma and several other malignancies. It is a derivative of mechlorethamine, another human developmental toxicant.
1992). The human teratogenic effect of cyclophosphamide. Teratology 45: 329. Nicholson, H. O. (1968). Cytotoxic drugs in pregnancy. Review of reported cases. J. Obstet. Gynaecol. Br. Commonw. 75: 307–312. Paladini, D. et al. (2004). Prenatal detection of multiple fetal anomalies following inadvertent exposure to cyclophosphamide in the first trimester of pregnancy. BDR (A) 70: 99–100. Russell, J. , Powles, R. , and Oliver, R. T. D. (1976). Conception and congenital abnormalities after chemotherapy of acute myelogenous leukemia in two men.
CHEMISTRY Cyclophosphamide is average in size compared to the other human developmental toxicants. It is hydrophilic and capable of interacting primarily as a hydrogen bond acceptor. The parent structure ultimately yields electrophilic metabolites (phosphoramide mustard). The calculated physicochemical and topological properties for cyclophosphamide are as follows. 244 Continued. 656 REFERENCES Adams, P. , Fabricant, J. , and Legator, M. S. (1981). Cyclophosphamide-induced spermatogenic effects detected in the F1 generation by behavioral testing.
Human Developmental Toxicants: Aspects of Toxicology and Chemistry by James L. Schardein (Author), Orest T. Macina (Author)