Gururaj Kalkeri, Ann D. Kwong (auth.), Joseph M. Colacino,'s Hepatitis Prevention and Treatment PDF

By Gururaj Kalkeri, Ann D. Kwong (auth.), Joseph M. Colacino, Beverly A. Heinz (eds.)

ISBN-10: 3034879032

ISBN-13: 9783034879033

ISBN-10: 3034896174

ISBN-13: 9783034896177

ISBN-10: 3764359560

ISBN-13: 9783764359560

Chronic viral hepatitis has emerged as some of the most universal factors of affliction and dying world wide. as a result of their exact modes of replication and intimate organization with the host immune approach, hepatitis B virus (HBV) and hepatitis C virus (HCV) pose hard difficulties to scientists in simple and utilized examine in addition to to clinicians engaged in illness administration. even if licensed antiviral remedy is obtainable for power HBV, the emergence of viral resistance offers a reason for the improvement of novel chemotherapeutic brokers. the shortcoming of a powerful mobilephone tradition approach for HCV replication and a without problems obtainable small-animal version of HCV an infection have hampered the improvement of antiviral brokers for HCV. Neverthe-less, new antiviral brokers concentrating on HCV at the moment are in preclinical and scientific development.

This monograph, offering an up to date evaluation of the sector of Hepatitis Prevention and remedy, comprises contributions from the world over well-known specialists within the box of viral hepatitis, and covers the present nation of data and perform concerning the molecular biology, immunology, biochemistry, pharmacology and scientific features of power HBV and HCV an infection. the quantity contains salient subject matters corresponding to: the historical past and epidemiology of HBV and HCV; fresh insights into the molecular mechanisms of viral replication; the host immune reaction to an infection and a dialogue of the use (HBV) or strength improvement (HCV) of vaccines; the present common of deal with chronically-infected sufferers; and rising treatments and concerns linked to present antiviral remedies. the newest info to researchers and clinicians actively engaged in viral hepatitis examine is equipped, but additionally enough history and dialogue of the literature to learn the newcomer to the field.

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Sample text

In Western Europe, a similar prevalence of HCV seropositivity has been demonstrated. 1 %. 6% [42], with 90% of Japanese patients having chronic liver disease attributable to HCV infection. Comparative sequence data from the HCV core, El and NS5 regions in the genomes of different HCV isolates have demonstrated that HCV exists as distinct genotypes that share approximately 70% sequence identity [43]. Several studies have shown that HCV genotypes have clinical significance with respect to disease progression and treatment outcomes [44, 45].

N Engl 1 Med 292: 767-770 88 Fetelson M (2002) Background of hepatitis C virus. In: M Fetelson (ed): Hepatitis C Virus from laboratory to Clinic. Cambridge University Press, Cambridge, 3-17 89 Prince AM, Brotman B, Grady GF, Kuhns WJ, Hazzi C, Levine RW, Millian SJ (1974) Long-incubation post-transfusion hepatitis without serological evidence of exposure to hepatitis-B virus. Lancet 2: 241-246 90 Alter HJ, Holland PV, Morrow AG, Purcell RH, Feinstone SM, Moritsugu Y (1975) Clinical and History of viral hepatitis 23 serological analysis of transfusion-associated hepatitis.

1996) Molecular cloning and disease association of hepatitis G virus: a transfusion-transmissible agent Science 271: 505-508 159 Alter MJ, Margolis HS, Krawczynski K, Judson FN, Mares A, Alexander WJ, Hu PY, Miller JK, Gerber MA, Sampliner RE et al. (1992) The natural history of community-acquired hepatitis C in the United States. The Sentinel Counties Chronic non-A, non-B Hepatitis Study Team. N Engl J Med 327: 1899-1905 160 Zuckerman AJ (1996) Alphabet of hepatitis viruses. Lancet 347: 558-559 161 Moaven LD, Hyland CA, Young IF, Bowden DS, McCaw R, Mison L, Locarnini SA (1996) Prevalence of hepatitis G virus in Queensland blood donors.

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Hepatitis Prevention and Treatment by Gururaj Kalkeri, Ann D. Kwong (auth.), Joseph M. Colacino, Beverly A. Heinz (eds.)

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