By Dr. Keith Hruska, Brenda Kurnik, Masaharu Tsutsumi (auth.), Shaul G. Massry, Giuseppe Maschio, Eberhard Ritz (eds.)
We are happy to provide to our readers the lawsuits of the 6th foreign Workshop on Phosphate and different Minerals which was once held in Verona, Italy, in the course of June 24-26, 1983. It used to be hosted through Professor Giuseppe Maschio, Professor of medication and leader, division of Nephrology on the collage of Verona. The 6th Workshop maintained the culture of the former ones. It supplied a special and impressive chance for shut interplay among scientist serious about the study of the final box of Mineral Metabolism. the present Workshop was once attended via 250 scientists from 15 international locations together with Austria, Canada, Denmark, England, France, Germany,Holland, Israel, Italy, Japan, Spain, Sweden,Switzerland, and the USA of the USA. the subjects mentioned integrated the renal dealing with of phosphate, shipping of alternative minerals, intestinal absorption of calcium and phosphate and phosphate homeostasis in overall healthiness and affliction. symposia facing the new advancements of the interactions among minerals, parathyroid hormone, and blood strain and among minerals and myopathies have been incorporated. as well as the 15 state of the art Lectures, there have been forty three oral and sixty three poster shows chosen from over two hundred abstracts sub mitted to this system Committee. The 7th overseas Workshop on Phosphate and different Minerals should be held in the course of September, 1985, in Marseille, France. it will likely be hosted by way of Professor Michel almer, leader of the dep. of Nephrology on the collage of Marseille. The subject matter of this coming Workshop will specialize in the pathophysiology of phosphate homeostasis and the metabolism of alternative minerals.
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Extra info for Phosphate and Mineral Metabolism
McIntosh, The effect of the admnistration of calcium salts on the inorganic composition of the blood, J. BioI. Chem. 60:327 (1924). 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. 16. 17. 18. H. E. H. H. Bassett, The fate of intravenously administered calcium. Effect on urinary calcium and phosphorus, fecal calcium and calcium-phosphorus balance, J. Clin. Invest. 29:1167 (1950). S. F. Neuman, Renal excretion of calcium by the dog, Am. J. Physiol. 180:623 (1955). H. D. Thompson, Some effects of intravenously administered calcium on inorganic phosphate metabolism, J.
If we attempt to separate the two systems of transport, by subtracting the uptake due 31 to the high affinity system from the total uptake measured with high substrate concentrations, the new Km obtained for the low affinity system is 17 roM, which is very high. Indeed it would appear logical to hypothesize a transport system whose Km remains within the range of natural concentrations of substrate in tubular fluid. Temperature modifies membrane fluidity and enzyme activity. It is normal therefore that uptake velocity varies with temperature.
Figure 1 shows that 3-mercaptopicolinate, which has no effect on phosphate accumulation in the absence of gluconeogenic substrate or in the presence of glycerol, does inhibit the phosphate accu mulation stimulated by pyruvate and perhaps succinate. n Glucose Production 100 QJ ...... c:I Phosphate Accumulation > .... ::J >Cl. c:I 50 0 -; E .... 1 m M 3-mercaptopicolinate after 2 minutes incubation. The bars show the means of 3 experiments relative to the effect of pyruvate (100%). 3 pM) was determined in addition to that of phosphate by duallabel scint:fllation counting.
Phosphate and Mineral Metabolism by Dr. Keith Hruska, Brenda Kurnik, Masaharu Tsutsumi (auth.), Shaul G. Massry, Giuseppe Maschio, Eberhard Ritz (eds.)