Download PDF by C. Gad Shayne: Animal Models in Toxicology 2nd Edition (Drug and Chemical

By C. Gad Shayne

ISBN-10: 0824754077

ISBN-13: 9780824754075

Reflecting greater than a decade’s worthy of adjustments, Animal versions in Toxicology, moment version is a pragmatic consultant to the typical statistical difficulties encountered in toxicology and the methodologies which are on hand to resolve them. The ebook offers a old overview of using animal versions and an summary of huge concerns of metabolism and relevance utilized in toxicology. person chapters protecting the 8 significant species utilized in toxicology and experimental biology shape the center of the ebook. With contributions from specialists in toxicology, toxicological pathology, and species-specific metabolism, each one of those chapters offer an outstanding introductory “course” besides assistance to the literature for extra targeted figuring out. The publication is going directly to make the case for a variety of species no longer prevalent for protection review reviews yet that can supply valuable substitute versions for a few particular endpoints. The bankruptcy authors speak about specific issues concerning theevaluation and interpretation of the scientific pathology of the 8 significant version species in addition to the way to choose a version species and the way to extrapolate the consequences to people. They aspect capability pitfalls and events that reason both human or version to be considerably extra delicate than the opposite or completely beside the point to one another. The booklet concludes with an outline of the more and more advanced legislation and rules that govern how laboratory animals are got, maintained, and applied, and an appendix that offers a brief advisor to advertisement resources of laboratory animals.

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Extra resources for Animal Models in Toxicology 2nd Edition (Drug and Chemical Toxicology)

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And Chengelis, C. (1998). ). San Diego, CA: Academic Press. , et al. (1974). Pathogenesis of lean encephalopathy: Uptake of lead and reaction of brain capillaries. Arch. Neuro. 31, 382–389. Gonzales, F. (1988). The molecular biology of cytochrome P-450s. Pharmacol. Rev. 40, 243–288. , and Schmelas, A. (1985). Age-development and inducibility of hepatic glutathione Stransfersase activities in mice, rats, rabbits and guinea-pigs. Comp. Biochem. Physiol. 80C, 85–90. , and Klaassen, C. (1983). Hepatic phase I and phase II biotransformations in quail and trout: Comparison to other species commonly used in toxicity testing.

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Animal Models in Toxicology 2nd Edition (Drug and Chemical Toxicology) by C. Gad Shayne

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