Hayes' Principles and Methods of Toxicology, Sixth Edition by A. Wallace Hayes, Claire L. Kruger PDF

By A. Wallace Hayes, Claire L. Kruger

ISBN-10: 1842145363

ISBN-13: 9781842145364

Hayes’ ideas and strategies of Toxicology has lengthy been verified as a competent connection with the innovations, methodologies, and checks imperative to toxicology. the recent 6th version has been revised and up-to-date whereas protecting a similar excessive criteria that experience made this quantity a benchmark source within the box. With new authors and new chapters that deal with the advances and advancements because the 5th variation, the ebook provides every little thing toxicologists and scholars want to know to appreciate risks and mechanisms of toxicity, permitting them to higher examine risk.

The ebook starts with the 4 simple rules of toxicology—dose concerns, humans vary, every thing transforms, and timing is essential. The participants talk about numerous brokers of toxicity, together with foodborne, solvents, crop safety chemical substances, radiation, and plant and animal pollutants. They research a number of tools for outlining and measuring toxicity in a bunch of parts, together with genetics, carcinogenicity, toxicity in significant physique platforms, and the surroundings. This re-creation includes an increased word list reflecting major alterations within the field.

New issues during this variation include:

  • The value of dose–response
  • Systems toxicology
  • Food safety
  • The humane use and care of animals
  • Neurotoxicology

The accomplished insurance and transparent writing type make this quantity a useful textual content for college kids and a one-stop reference for pros. Readers have complimentary entry to an internet model of the broadcast book.

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Extra info for Hayes' Principles and Methods of Toxicology, Sixth Edition

Sample text

His contributions to the advancement of medicine are legendary, due in great measure to his belief that the causes of diseases were natural and not supernatural. Writings attributed to him rejected the superstition and magic of primitive medicine and laid the foundations of medicine as a branch of science. Like other Greek physicians, he believed that health was the result of an equilibrium or balance in the body among the humors (blood, black bile, yellow bile, and mucus) and that disequilibrium resulted in ill health.

Understanding poisons—to control them or avoid them—has therefore been an integral part of our past. As our understanding of poisons progressed, a unique field of knowledge grew into the science of toxicology. This chapter captures toxicology’s wissenschaften, its emergence as a distinct field of study from its vague, sometimes dark, beginnings. Toxicology passed through a number of phases during its maturation into a recognized discipline. These include the use of poisons to kill, listing poisons and their effects (observation/phenomenology), guessing at possible antidotes, identifying occupational causes of disease, detection of poisons, experimentation to deduce the mechanisms of toxicity, development of rational therapeutic measures, and finally quantification of effects.

Part of Pompey’s army was rendered helpless to repel their attackers and many were killed. Pompey eventually prevailed over Mithridates and found the prescription for mithridatum. He sent it to Rome where efforts to improve upon it were made (described in the following). It is said that when Mithridates saw that people supported his son over him, he attempted to take his own life, but failed because of the resistance he had built up to poison. He had to ask one of his mercenary soldiers to kill him with a sword.

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Hayes' Principles and Methods of Toxicology, Sixth Edition by A. Wallace Hayes, Claire L. Kruger

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