By Rajesh K. Naz
"Endocrine Disruptors: results on female and male Reproductive structures, moment version examines the reproductive and future health risks of endocrine-disrupting environmental chemical compounds from epidemiology to etiology, concluding with destiny instructions. prime experts give a contribution specialist analyses and up to date info on an issue that has turn into an incredible problem one of the medical neighborhood and the final public." "Divided into sections, the 1st a part of the ebook describes the consequences of environmental toxicants at the woman reproductive approach, with an emphasis at the results and mechanisms in their motion on intercourse differentiation in the course of improvement, fertility, and breast melanoma. the second one half addresses the results of endocrine disruption at the male reproductive method, concentrating on male fertility and the advance of benign prostate hyperplasia (BPH) and prostate cancer."--BOOK JACKET. Read more...
content material: part I impression at the woman Reproductive process --
Disruption of Nongenomic Steroid activities on Gametes and Serotonergic Pathways Controlling Reproductive Neuroendocrine functionality by way of Environmental chemical substances --
Developmental and Reproductive Abnormalities linked to Environmental Estrogens: Diethylstilbestrol (DES) for example Ovotoxic Environmental chemical compounds: oblique Endocrine Disruptors --
p,p'-DDE and HCB: Mechanisms of Toxicity to Fetal and Embryonic Mammalian Cells --
nutritional Phytoestrogens --
Estrogens, Xenoestrogens and the improvement of Neoplasms --
Molecular Mechanisms of Endocrine Disruption in Estrogen established methods --
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and comparable Environmental Antiestrogens: Characterization and Mechanism of motion --
part II impact at the Male Reproductive procedure --
Endocrine Disruptors and Male Infertility --
Environmental Androgens and Antiandrogens: An increasing Chemical Universe --
Endocrine Disruptors and Male Sexual disorder --
Prostate improvement: Mechanisms for contrary results of high and low Doses of Estrogenic chemical substances --
steel Ions as Endocrine Disruptors: Implications for Prostate Cancer.
summary: "Endocrine Disruptors: results on female and male Reproductive platforms, moment version examines the reproductive and healthiness risks of endocrine-disrupting environmental chemical substances from epidemiology to etiology, concluding with destiny instructions. top professionals give a contribution specialist analyses and up to date info on a subject that has turn into an immense main issue one of the medical neighborhood and the final public." "Divided into sections, the 1st a part of the booklet describes the results of environmental toxicants at the lady reproductive process, with an emphasis at the results and mechanisms in their motion on intercourse differentiation in the course of improvement, fertility, and breast melanoma. the second one half addresses the results of endocrine disruption at the male reproductive process, concentrating on male fertility and the advance of benign prostate hyperplasia (BPH) and prostate cancer."--BOOK JACKET
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Extra resources for Endocrine disruptors : effects on male and female reproductive systems
And Sokol, R. , Effects of toxic levels of lead on gene regulation in the male axis: increase in messenger ribonucleic acids and intracellular stores of gonadotrops within the central nervous system, Biol. , 50, 802, 1994. 31. , Effects of cadmium on gonadotropin secretion from Atlantic croaker pituitaries incubated in vitro, Mar. Environ. , 35, 141, 1993. 32. Cooper, R. , Goldman, J. , Rehnberg, G. , McElroy, W. , and Hein, J. , Effects of metal cations on pituitary hormone secretion in vitro, J.
McLachlan, J. , and Korach, K. , Peptide growth factor cross-talk with the estrogen receptor requires the A/B domain and occurs independently of protein kinase C or estradiol, Endocrinology, 137, 1735, 1996. 18. , 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds as antiestrogens: characterization and mechanism of action, Pharmacol. , 64, 400, 1991. 19. , Antiestrogenic effects of 2,3,7,8-tetracholorodibenzo-pdioxin are mediated by direct transcriptional interference with the liganded estrogen receptor, J.
Therefore, one of the reasons for the lower pituitary GnRH-R concentrations observed in PCB-exposed croaker  might be insufficient GnRH release from the pituitary nerve terminals, resulting in reduced up-regulation of the GnRH-R. The finding that the low-dose GnRHa implants up-regulated GnRH-R, increased basal LH secretion, and fully restored the LH response to GnRHa in PCB-exposed croaker is consistent with a mechanism of PCB toxicity involving decreased GnRH secretion. 11 Effects of PCB alone and in combination with the GnRHa implants on the GnRH receptor (GnRH-R) content (A), and on the basal (saline) and GnRHa-induced LH secretion (B).
Endocrine disruptors : effects on male and female reproductive systems by Rajesh K. Naz