By James Devillers
ISBN-10: 1420076353
ISBN-13: 9781420076356
Makes use of Computational instruments to Simulate Endocrine Disruption Phenomena Endocrine Disruption Modeling offers a pragmatic review of the present ways for modeling endocrine job and the similar power hostile results they could set off on environmental and human future health. in keeping with the vast examine of a world panel of members from undefined, academia, and regulatory companies, this can be the 1st publication dedicated to utilizing machine instruments to raised comprehend and simulate the multifaceted points of endocrine disruption in people and natural world. Explores diversified Modeling recommendations and functions This up to date source specializes in xenobiotics which are by accident published into the surroundings with the capability to disturb the traditional functioning of the endocrine procedure of invertebrates and vertebrates but in addition at the particular agro-chemistry layout of chemical compounds that take regulate of insect endocrine structures. A accomplished examine reference, Endocrine Disruption Modeling presents a suite of computational thoughts to version those structurally different chemical compounds. It concludes with a evaluate of the on hand e-resources within the box, rounding out the book’s task-oriented method of destiny EDC discovery. Endocrine Disruption Modeling is the 1st e-book within the QSAR in Environmental and overall healthiness Sciences sequence (James Devillers, j.devillers@ctis.fr).
Read or Download Endocrine Disruption Modeling (QSAR in Environmental and Health Sciences) PDF
Best toxicology books
Get Preclinical Development Handbook: Toxicology PDF
A transparent, user-friendly source to steer you thru preclinical drug developmentFollowing this book's step by step counsel, you could effectively start up and entire serious stages of preclinical drug improvement. The ebook serves as a basic,comprehensive connection with prioritizing and optimizing leads, toxicity, pharmacogenomics, modeling, and laws.
The Role of Glia in Neurotoxicity, Second Edition by Michael Aschner, Lucio G. Costa PDF
Proposing the most recent learn in glial phone functionality gleaned from new recommendations in imaging and molecular biology, The position of Glia in Neurotoxicity, moment version covers a number of facets of glial cells, together with morphology, body structure, pharmacology, biochemistry, pathology, and their involvement within the pathophysiology of neurological ailments.
William A. Moats and Marjorie B. Medina (Eds.)'s Veterinary Drug Residues. Food Safety PDF
Content material: stable animal husbandry perform and residues within the usa / Lester M. Crawford -- Human future health dangers linked to drug residues in animal-derived meals / S. F. Sundlof and J. Cooper -- shopper perceptions and issues approximately veterinary drug residues / Christine M. Bruhn -- eu Union regulatory residue research of veterinary medicinal drugs : a strategic process / R.
- Adverse Effects of Engineered Nanomaterials. Exposure, Toxicology, and Impact on Human Health
- Carbon Monoxide Poisoning - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References
- Handbook of Toxicology of Chemical Warfare Agents
- Handbook of Laboratory Animal Science, Volume II, Third Edition: Animal Models
- Deja Review Pharmacology, Second Edition
Additional resources for Endocrine Disruption Modeling (QSAR in Environmental and Health Sciences)
Example text
Other nuclear receptors, such as CAR and PXR, appear to function as xenobiotic sensors up-regulating the expression of cytochrome P450 enzymes that metabolize these xenobiotics. 1 ESTROGEN RECEPTORS AS A TARGET FOR ENDOCRINE DISRUPTION Initial concern regarding EDCs was focused on environmental estrogens. Estrogenic compounds exert pleiotropic effects in wildlife and humans, and endogenous estrogens, like 17D-estradiol, regulate growth and development of their target tissue. A vast range of both natural and man-made steroidal and nonsteroidal compounds has been investigated for estrogen activities.
J. Christensen, H. D. B. M. -Y. M. T. P. M. Fowlkes, Estrogen receptor (ER) modulators each induce distinct conformational changes in ERC and ERD, Proc. Natl. Acad. Sci. USA 96 (1999), pp. 3999–4004. J. Kushner, P. M. M. H. Price, Estrogen receptor action through target genes with classical and alternative response elements, Pure Appl. Chem. 75 (2003), pp. 1757–1769. [22] K. Pettersson, F. A. Gustafsson, Estrogen receptor D acts as a dominant regulator of estrogen signaling, Oncogene 19 (2000), pp.
Health Part B Crit. Rev. 1 (1998), pp. 347–371. R. B. J. R. A. Rokosh, Impact of bleached kraft mill effluent on population characteristics, liver MFO activity, and serum steroid levels of a Lake Superior white sucker (Catastomus commersoni) population, Can. J. Fish. Aquat. Sci. 48 (1991), pp. 1371–1380. [48] E. Neuman and P. Karas, Effects of pulp mill effluent on a Baltic coastal fish community, Water Sci. Technol. 20 (1988), pp. 95–106. [49] G. Van der Kraak, T. M. B. W. Gooch, Comparative endocrinology and mechanisms of endocrine modulation in fish and wildlife, in Principles and Processes for Evaluating Endocrine Disruption in Wildlife, R.
Endocrine Disruption Modeling (QSAR in Environmental and Health Sciences) by James Devillers
by Ronald
4.5