By Christof Schaefer, Paul W. J. Peters, Richard K Miller
The most recent variation is the source for any training OB/GYN, kin doctor, midwife, or pharmacist who prescribes medicinal items to or evaluates environmental or occupational exposures in ladies who're or may well develop into pregnant. in response to the hugely winning seven German variants of this reference, the up to date drug listings were revised right into a convenient pocket consultant colour tabbed for fast entry to big info. effortless to reference every one drug is indexed discussing the negative effects, common effect on organ structures, capability toxicity, and dangers sooner than providing dosage thoughts. it's the purely e-book of its variety to supply conclusive details on remedies for illnesses while pregnant and lactation and activities to be taken after (inadvertant) publicity to medicines suspected to be developmentaly poisonous. not like different dosage courses, this version is a reasonable, compact compendium of data at the very most recent medications and their results on pregnant/lactating girls. * presents conclusive info at the prevention of beginning defects during the secure use of gear earlier than being pregnant, in addition to while pregnant and lactation * crucial new info on herbs, supplementations, and meals vitamins used while pregnant * established in accordance with indication staff, instead of alphabetically, delivering a extra effortless consultant that makes it more uncomplicated to match medicinal drugs * features a with ease detachable 'quick reference' card of most often used medicines and their security
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Additional info for Drugs During Pregnancy and Lactation (Schaefer, Drugs During Pregnancy and Lactation), 2nd Edition
Elias SG, van Noord PA, Peeters PH et al. Childhood exposure to the 1944–1945 Dutch famine and subsequent female reproductive function. Hum Reprod 2005; 20: 2483–8. Fisher JS. Environmental anti-androgens and male reproductive health: focus on phthalates and testicular dysgenesis syndrome. Reproduction 2004; 127: 305–15. Friedman JM. Implications of research in male-mediated developmental toxicity to clinical counsellors, regulators, and occupational safety officers. Adv Exp Med Biol 2003; 518: 219–26.
Principle 2 Not all mammalian species are equally susceptible or sensitive to the reproductive toxic influence of a given chemical. The inter- and intraspecies variability may be manifested in several ways: a drug that acts in one species may have little or no effects in others; a reproductive toxicant may produce similar defects in various species, but these defects will vary in frequency; a substance may induce certain developmental disorders in one species that are entirely different from those induced in others.
The FDA classification as published in the Federal Register (2000) is not much different from the earlier one indicated in the previous edition of this book as being under “reconstruction”. In the EU, a specification of the medicinal products to be used in pregnancy has to be given on the summary of product characteristics, including: ■ ■ ■ 1 facts regarding human experience and conclusions from preclinical toxicity studies which are of relevance for the assessment of risks associated with exposure during pregnancy recommendations on the use of the medicinal product at different times during pregnancy in respect of gestation recommendations on the management of the situation of an inadvertent exposure, where relevant.
Drugs During Pregnancy and Lactation (Schaefer, Drugs During Pregnancy and Lactation), 2nd Edition by Christof Schaefer, Paul W. J. Peters, Richard K Miller