Download e-book for iPad: Comprehensive Virology: Vol 15: Virus-Host Interactions by Michael B. A. Oldstone (auth.), Heinz Fraenkel-Conrat,

By Michael B. A. Oldstone (auth.), Heinz Fraenkel-Conrat, Robert R. Wagner (eds.)

ISBN-10: 1461330092

ISBN-13: 9781461330097

ISBN-10: 1461330114

ISBN-13: 9781461330110

The time turns out ripe for a severe compendium of that section of the organic universe we name viruses. Virology, as a technology, having handed only in the near past via its descriptive section of naming and num­ bering, has most likely reached that level at which particularly few new-truly new-viruses can be came upon. brought on via the highbrow probes and strategies of molecular biology, genetics, bio­ chemical cytology, and excessive answer microscopy and spec­ troscopy, the sector has skilled a real info explosion. Few critical makes an attempt were made to chronicle those occasions. This finished sequence, as a way to include a few 6000 pages in a complete of approximately 18 volumes, represents a dedication through a wide crew of lively investigators to investigate, digest, and expostulate at the nice mass of knowledge on the subject of viruses, a lot of that is now amorphous and disjointed, and scattered all through a large literature. during this method, we are hoping to put the whole box in point of view, and to increase an invalua­ ble reference and sourcebook for researchers and scholars in any respect degrees. This sequence is designed as a continuum that may be entered at any place, yet which additionally presents a logical development of constructing proof and built-in concepts.

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Further, the accompanying release of lymphokines such as interferon may affect immune responses. These interactions between viruses and cells of the immune system have been analyzed predominantly in vitro and rarely in vivo. Most studies show that resting lymphocytes and macrophages or particular sUbpopulations of lymphocytes in cultures can be infected with various DNA and RNA viruses and that, on activation, the permissive lymphocytes express viral antigens and replicate infectious virus. Adding biological significance to these in vitro observations is the increasing number of reports that viruses can replicate for long periods in lymphocytes and macrophages of infected, intact animals.

Cytotoxic T cells generated during acute LCMV infection; A· -. -. A, cytotoxic T cells generated during acute Pichinde virus infection. From M. Buchmeier, R. Ott, and M. Oldstone (unpublished data). T -cell killing (Table 3). Taken in toto, these reports suggest that cytotoxic T cells are present in persistently infected mice and indicate mechanisms whereby such cell-mediated immune responses can be blocked. 4. Retrovirus Models The findings with experimental retrovirus infection parallel those with LCMV infection in mice.

1975b, A gene locus affecting tolerance to BGG in mice, Cell. Immunol. 15:457. , 1969, Interaction between antigenically different cells: Virus induced cytotoxicity by immune lymphocytes in vitro, Acta Pathol. Microbiol. Scand. 75:134. , 1976, Replication of Dengue virus in cultures of peripheral blood leukocytes from Dengue-immune rhesus monkeys, J. Infect. Dis. 133:274. , 1973, In vitro measurement of the time course of cellular immunity to LCM virus in mice, in: Lymphocytic Choriomeningitis Virus and Other Arenaviruses (F.

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Comprehensive Virology: Vol 15: Virus-Host Interactions Immunity to Viruses by Michael B. A. Oldstone (auth.), Heinz Fraenkel-Conrat, Robert R. Wagner (eds.)

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