By Seymour Ehrenpreis
The busy healthcare practitioner's first reference for well timed, exact, and appropriate drug details. Alphabetically prepared via customary identify (with exchange names cross-referenced) and awarded in an at-a-glance drug chart layout. All entries are reviewed through a piece of writing advisory board of educational an medical gurus.
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Extra resources for Clinician's Handbook of Prescription Drugs
Indications/dosage/route: Oral only. • Mild gout – Adults: 200–300 mg/d. • Moderate or severe gout – Adults: 400–600 mg/d. • Prophylaxis against acute attack – 100 mg/d. Maximum: 800 mg/d. • Prevention of hyperuricemia during cancer chemotherapy – Adults, children >10 years: 600–800 mg/d, 2–3 divided doses, 1–2 days before chemotherapy for 2–3 days. IV 200–400 mg/m2/d. – Children <10 years: 200–300 mg/m2/d, 2–4 divided doses. IV 200–300 mg/m2/d. Adjustment of dosage • Kidney disease: Adjust dosage in relation to creatinine clearance.
Women with genital herpes should have annual Pap smears. • Rapid bolus administration may cause crystalline precipitation in renal tubules and renal insufficiency. • Patients receiving acyclovir IV must remain well hydrated during treatment and for 24 hours after treatment. • Cases of thrombotic thrombocytopenic purpura/hemolytic uremia syndrome have been reported with high-dose acyclovir in immunocompromised patients. Advice to patient • Drink 2–3 L of fluid per day. This is particularly important following IV infusion.
D. for 10 days. • Herpes simplex encephalitis – Adults, children >12 years: IV 10 mg/kg (infuse at constant rate over 1 hour), q8h for 10 days. – Children, 6 months to 12 years: IV 500 mg/m2 (infuse at constant rate over 1 hour), q8h for 10 days. • Herpes zoster – Adults, children >12 years: PO 80 mg, q4h, five doses/day, 7–10 days. – Children <12 years: PO 250–600 mg/m2, 4–5 times/day, 7–10 days. d. 5 days. d. (maximum 800 mg), 5 days. 8 ACYCLOVIR Adjustment of dosage • Kidney disease: Creatinine clearance 25–50 mL/min: dose q12h; creatinine clearance 10–25 mL/min: dose q24h; creatinine clearance <10 mL/min: half dose q24h (IV doses).
Clinician's Handbook of Prescription Drugs by Seymour Ehrenpreis