Download PDF by Stephen C. Mitchell: Biological Interactions Of Sulfur Compounds

By Stephen C. Mitchell

ISBN-10: 0203362527

ISBN-13: 9780203362525

ISBN-10: 0748402454

ISBN-13: 9780748402458

This article makes a speciality of the organic interactions of sulphur compounds which come up in particular from the presence of the sulphur atom in the molecule. The publication opens with introductory chapters at the chemistry and biology of sulphur, earlier than tackling the sphere through introducing compounds which proportion a typical chemical blend. often, following an outline of the makes use of and effect upon the organic box, particular chemical workforce features are mentioned including the organic task and structure-activity relationships the place identified. The toxicity of such compounds, their outcomes in biochemical and scientific phrases, and their mechanisms of organic interplay are then addressed.

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1979, Perry et al. 1985). Errors in the metabolism of the sulfur amino acids within the CNS have been found to be relatively common and may be accompanied by serious neuropsychiatric disorders, with unusual sulfur-amino acids being observed in urine samples obtained from such patients (Ampola et al. 1969, Irreverre et al. 1967, Mudd and Levy 1983, Olney et al. 1975). Cysteine, if permitted to accumulate within the body, is known to be neurotoxic, as are cysteinsulfinic and cysteic acids; neuronal degeneration results from an overactivation of receptors.

M. ), Metabolism of S&fur Compounds: Metabolic Pathways, Vol. 7, 3rd Edn, pp. l-25, London: Academic Press. AMONKAR, S. V. , 1971, Isolation and characterisation of larvicidal principal of garlic, Science, 174, 1343-1344. AMPOLA, M. , EFRON, M. , BIXBY, E. M. , 1969, Mental deficiency and a new aminoaciduria. American Journal of Diseases in Children, 117, 66-70. AULT, W. V. & KULP, J. , 1959, Isotopic geochemistry of sulphur. Geochimica Cosmochimica Acta, 16, 201-235. , MIZUO, H. , 1980, Microassay of cysteine sulfinic acid by an enzymatic cycling method, Analytical Biochemistry, 101, 288293.

1977). This places the enzyme, and its metabolic products, in a position to fulfil a regulatory role. The neuroexcitatory actions of cysteinsulfinic acid and the antagonistic effects of taurine suggests a means by which excitatory and inhibitory amino acids may interact to modulate neuronal excitability and this may be significant for neuronal functions (Baba et al. 1982, 1983, 1985, Iwata and Baba 1983). Hallervorden-Spatz disease, a rare neurological disorder inherited in an autosomal recessive fashion which gives rise to choreic or athetoid movements with general bradykinesia, rigidity and progressive mental deterioration, has been linked with cysteine accumulation and cysteine dioxygenase deficiency in the globus pallidus and substantia nigra areas of the brain (Elejalde et al.

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