Read e-book online Autoimmune Reactions PDF

By Sudhir Paul (auth.), Sudhir Paul (eds.)

ISBN-10: 0896035506

ISBN-13: 9780896035508

ISBN-10: 1461216109

ISBN-13: 9781461216100

ISBN-10: 1461272157

ISBN-13: 9781461272151

Autoimmune Reactions tackles basic questions on how the immune approach can break invading microbial pathogens with no inflicting harm to itself and different "self" platforms. The authoritative specialists writing the following discover the mechanistic facets of such autoimmune illnesses as lupus, rheumatoid arthritis, diabetes, and autoimmune thyroid affliction, and the place attainable delineate how malfunctioning immunological mechanisms can result in medical signs. additionally they speak about attainable common mechanisms of autoimmune disease-e.g., molecular mimicry and dysfunctional antigen presentation-and their present boundaries as unifying motives of the ailments defined. additionally, proof for novel immunological phenomena, together with antibody catalysis and the penetration of cells via antibodies, is reviewed, and their attainable organic results are pointed out. The e-book additionally severely surveys the strategies and study that are meant to finally let improvement of palliatives and therapies for autoimmune illnesses, in addition to ways to the long-standing challenge of self-nonself discrimination by way of the immune system.

the great, insightful review supplied in Autoimmune Reactions constitutes the hot typical reference for all practising autoimmunologists, molecular immunologists, mobile and molecular pathologists, and medical immunologists who have to stay on the state of the art of analysis on autoimmune sickness this day.




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Sthoeger, Z. , Tse, D. , Vinciguerra, V. , Allen, S. , Budman, D. , et al. (1989) Production of autoantibodies by CD5-expressing B lymphocytes from patients with chronic lymphocytic leukemia. J. Exp. Med. 169, 255-268. 55. , Binet, J. , and Dighiero, G. (1990) Evidence that chronic lymphocytic leukemia B lymphocytes are frequently committed to productions of natural autoantibodies. Blood 76, 562-569. 56. Kipps, T. , Chen, P. , and Carson, D. A. (1988) Autoantibody associated K light chain variable region gene expressed in chronic lymphocytic leukemia with little or no somatic mutation, implications for etiology and immunotherapy.

Martin, S. E. and Martin, W. 1. (1975) Interspecies brain antigen detected by naturally occurring mouse anti-brain auto-antibody. Proc. Natl. Acad. Sci. USA 72, 1036-1041. 11. Martin, W. 1. and Martin, S. E. (1975) Thymus reactive IgM auto-antibodies in normal mouse sera. Nature 254, 716-718. 12. Sela, B. , Wang, J. , and Edelman, G. M. (1975) Antibodies reactive with cell surface carbohydrates. Proc. Natl. Acad. Sci. USA 72, 1127-1132. 13. MacKay, I. R. (1983) Natural autoantibodies to the fore - forbidden clones to the rear?

Mazie, J. , Butler-Browne, G. , Whalen, R. , et al. (1983) Murine hybridomas secreting natural monoclonal antibodies reacting with self antigens. J. Immunol. 131, 2267-2272. 21. , and Avrameas, S. (1985) High frequency of natural autoantibodies in normal newborn mice. J. Immunol. 134,765-771. 22. Dighiero, G. (1995) Natural autoantibodies in humans: their relevance in auto-immunity and lymphoproliferative disorders. Forum. Trends Exp. CZin. Med. 5,58-71. 23. Casali, P. and Notkins, A. L. (1988) Probing the human B-cell repertoire with EBV.

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Autoimmune Reactions by Sudhir Paul (auth.), Sudhir Paul (eds.)


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