By Mark Vézina B.Sc (auth.), Andrea B Weir, Margaret Collins (eds.)
Ocular toxicity is oftentimes assessed in toxicology stories performed for regulatory reasons. Ocular anatomy and body structure and the evaluate of ocular toxicity itself might be demanding to scientists desirous about the security evaluation of prescription drugs, insecticides and different brokers. Anatomical and physiological changes among species can effect the character of ocular results saw following meant or unintentional publicity of ocular tissues to xenobiotics. Ocular Toxicity in Laboratory Animals offers a concise reference addressing ocular anatomy and body structure throughout species that may improve the layout and interpretation of toxicology experiences carried out for regulatory reasons.
The ebook presents an outline of regimen and complicated strategies which are used to evaluate ocular toxicity together with slit lamp biomicroscopy, oblique ophthalmoscopy, electrophysiology and imaging tools for the anterior and posterior segments of the attention. also, the publication defines the regulatory expectancies for prescribed drugs meant to regard ocular ailments and for different non-pharmaceutical regulated chemical compounds. With contributions from specialists within the box, Ocular Toxicity in Laboratory Animals is an authoritative, obtainable consultant for toxicologists and different scientists inquisitive about carrying out toxicology experiences for regulatory reasons and/or reviewing info from such studies.
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Extra resources for Assessing Ocular Toxicology in Laboratory Animals
Electron microscopy of the tapetum lucidum of the cat. J Biophys Biochem Cytol. 1959;5:35–40. 5. Bill A. Conventional and uveo-scleral drainage of aqueous humour in the cynomolgus monkey (Macaca irus) at normal and high intraocular pressures. Exp Eye Res. 1966;5:45–51. 6. Bill A. Uveoscleral drainage of aqueous humor: physiology and pharmacology. In: The ocular effects of prostaglandins and other eicosanoids. New York: Alan R Liss; 1989. 7. Bill A, Hellsing K. Production and drainage of aqueous humor in the cynomolgus monkey (Macaca irus).
10 The indirect ophthalmoscope with lenses of varying dioptric powers allows great flexibility for examining the ocular fundus with varying magnification. 5% phenylephrine). By this examination, changes in vitreous, retina, vessels of the retina and choroid, and the optic disc may be evaluated. The direct ophthalmoscope provides a highly magnified but monocular view of the real (neither inverted nor reversed) image of the fundus, while the indirect ophthalmoscope provides a binocular view of an inverted and reversed aerial image obtained by the positioning of a condensing or converging lens between the eye and the examiner.
This examination technique and ophthalmoscopic examination of the ocular fundus form the mainstay of ocular examinations for the in-life portion of toxicology studies. Both table-mounted (Fig. 1) and portable (Fig. 2) models of slit-lamp biomicroscopes are available. Portable models are less expensive and more versatile for 2 Assessment of Ocular Toxicity Potential: Basic Theory and Techniques 27 Fig. 2 The Kowa handheld slit lamp offers good optics and portability for the examination of eye in animals that are not sedated or that cannot be easily presented for examination by a tablemounted slit-lamp biomicroscope exams of animals in a variety of situations than the table-mounted models.
Assessing Ocular Toxicology in Laboratory Animals by Mark Vézina B.Sc (auth.), Andrea B Weir, Margaret Collins (eds.)