By Keith Green (auth.), Keith Green, Henry F. Edelhauser, Robert B. Hackett, David S. Hull, David E. Potter, Ramesh C. Tripathi (eds.)
This quantity represents the lawsuits of the 5th Congress of the overseas Society of Ocular Toxicology (ISOT), which was once held on the Grove Park resort and hotel in Asheville, North Carolina, October 13-17, 1996. we're thrilled to offer this quantity to the ophthalmic group, in particular people with an important curiosity in ocular toxicol ogy. The 5th Congress used to be constructed round topics with regards to ocular drug metabolism, the ocular pathophysiological results of nitric oxide, executive concerns with regards to using replacement tools for toxicity trying out, and a workshop that encompassed comparisons of either in vitro as opposed to in vivo versions in addition to varied animal types. the end result of this congress, embodied during this quantity, is a contribution to the methodologies presently hired or less than improvement and to varied drug or actual results on diversified ocular tissues. whereas the focal point of this court cases is on ocular results of substances or different fabrics, a number of the contributions take care of themes that experience a much wider curiosity. The workshop in regards to the use of other version platforms and the alternative of the easiest animal version for drug checking out covers quite a lot of pursuits that ex has a tendency a ways past particular ocular results. this is often very true within the quarter of other tools and within the number of the easiest animal version for exam of other illness entities.
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Additional info for Advances in Ocular Toxicology
Williams KK, Woods WD, Edelhauser HF. Corneal diffusion and metabolism of 12(R)-hydroxyeicosatetraenoic acid (12(R)HETE). Curr Eye Res 1996;15:852-859. 9. Geroski DH, Kies JC, Edelhauser HF. The effects of ouabain on endothelial function in human and rabbit corneas. Curr Eye Res 1984;3:331-338. 10. Mills JW.. The cell cytoskeleton: Possible role in volume control. Curr Top Membrane Transport 1987;30:75--101. II. Kleinzeller A, Zlyadeh FN. Cell volume regulation in epithelia-with emphasis on the role of osmolyles and the cytoskeleton.
3. Davis KL, Conners MS, Dunn MW, Schwartzman ML. Induction of corneal epithelial cytochrome P450 arachidonate metabolism by contact lens wear. Invest Ophthalmol Vis Sci 1992;33:291-297. 4. Conners MS, Stoltz RA, Webb SC, Rosenberg J, Dunn MW, Abraham NG, Schwartzman ML. A closed eye contact lens model of corneal inflammation. Part I: Increase synthesis of cytochrome P450 arachidonic acid metabolism. Invest Ophthalmol Vis Sci 1995;36:828--840. 5. Conners MS, Stoltz RA, Davis KL, Dunn MW, Abraham NG, Levere RD, Schwartzman ML.
DaSilva J-L, Tiefenthaler M, Park E, Escalante B, Schwartzman ML, Abraham NG. Tin mediated heme oxygenase gene activation and cytochrome P450 arachidonate hydroxylase inhibition in spontaneously hypertensive rats. Am J Med Sci 1994; 70: 173-181. 2 THE EFFECTS OF 12(R)HETE AND ITS METABOLITE 8(R)HHDTrE ON CORNEAL ENDOTHELIAL FUNCTION Henry F. Edelhauser, K. Keven Williams, Glenn P. Holley, and Wendell D. Woods Department of Ophthalmology Emory University Atlanta, Georgia 1. INTRODUCTION The purpose of this presentation is twofold: (1) to summarize our studies as to the direct effect of 12(R)HETE, 8(R)HHDTrE on the corneal endothelium, and (2) to illustrate the diffusion and metabolism of 12(R)HETE by the cornea.
Advances in Ocular Toxicology by Keith Green (auth.), Keith Green, Henry F. Edelhauser, Robert B. Hackett, David S. Hull, David E. Potter, Ramesh C. Tripathi (eds.)