By Curtis Klaassen
ISBN-10: 0071124535
ISBN-13: 9780071124539
ISBN-10: 0071347216
ISBN-13: 9780071347211
The such a lot relied on all-in-one review of the biomedical and environmental points of toxicology--NOW extra whole, updated, and in complete color
A Doody's center name for 2015!
NEW to the 8th Edition
- FULL-COLOR layout to permit for a clearer interpretationof the fundamental elements of toxicology featured during the textual content
- EXPANDED tables, illustrations, and different visuals areupdated with cutting-edge criteria that makes thisedition much more present and correct
- DVD with picture financial institution gains all tables and illustrations from the textual content in presentation-ready structure
- NEW CHAPTERS comprise "Toxic results of Calories"and "Toxic results of Nanoparticles"
The world's prime and so much authoritative textbook on poisons has extra to provide students,toxicologists, and pharmacologists than ever prior to. Now in complete colour, and punctiliously revised, the 8th version of Casarett & Doull's TOXICOLOGY: the elemental technological know-how of Poisons not just promises a finished overview of the basic parts of toxicology, it bargains the main up-to-date,revealing, and in-depth examine the systemic responses of poisonous substance on hand anywhere.
Combined with the newest considering via the field's most efficient students plus sturdy insurance of basic ideas, modes of motion, and chemical-specific toxicity, this landmark textual content keeps to set the normal for toxicology references.
Read or Download Toxicology science of poisons PDF
Best toxicology books
Download PDF by Shayne Cox Gad: Preclinical Development Handbook: Toxicology
A transparent, common source to lead you thru preclinical drug developmentFollowing this book's step by step suggestions, you could effectively begin and whole severe stages of preclinical drug improvement. The booklet serves as a basic,comprehensive connection with prioritizing and optimizing leads, toxicity, pharmacogenomics, modeling, and rules.
Download PDF by Michael Aschner, Lucio G. Costa: The Role of Glia in Neurotoxicity, Second Edition
Featuring the newest examine in glial cellphone functionality gleaned from new recommendations in imaging and molecular biology, The function of Glia in Neurotoxicity, moment version covers a number of elements of glial cells, together with morphology, body structure, pharmacology, biochemistry, pathology, and their involvement within the pathophysiology of neurological illnesses.
Content material: solid animal husbandry perform and residues within the usa / Lester M. Crawford -- Human overall healthiness dangers linked to drug residues in animal-derived meals / S. F. Sundlof and J. Cooper -- buyer perceptions and issues approximately veterinary drug residues / Christine M. Bruhn -- eu Union regulatory residue research of veterinary medications : a strategic process / R.
- Toxic Chemicals in the Workplace: A Manager's Guide to Recognition, Evaluation, and Control
- A world-wide survey of new data and trends in adverse drug reactions
- Aspirin Overdose: A Medical Dictionary, Bibliography, And Annotated Research Guide To Internet References
- Cardiovascular toxicology
- Animal Clinical Chemistry - A Practical Handbook for Toxicologists and Biomedical Researchers
- Toxicogenomics-Based Cellular Models. Alternatives to Animal Testing for Safety Assessment
Extra info for Toxicology science of poisons
Sample text
However, genetic polymorphism may have other important but less dramatic effects than those described for acute idiosyncratic responses (such as that occurring in pseudocholinesterase-deficient individuals after succinylcholine exposure). For example, it is recognized that approximately 50 percent of the Caucasian population has a gene deletion for the enzyme glutathione S-transferase M1. , those who lack both copies of the normal gene) are functionally and physiologically normal. However, epidemiologic studies have indicated that smokers who are homozygous for the null allele may be at slightly increased risk of developing lung cancer compared with smokers who have one or both copies of the normal gene (Houlston, 1999; Strange and Fryer, 1999).
Theoretically, if no cumulative effect occurs over the doses, the chronicity index will be 1. If a compound were absolutely cumulative, the chronicity index would be 90. Statistical procedures similar to those used to calculate the LD50 can also be used to determine the lethal time 50 (LT50), or the time required for half the animals to die (Litchfield, 1949). The LT50 value for a chemical indicates the time course of the toxic effects but does not indicate whether one chemical is more toxic than another.
Two chemicals known to produce dispositional tolerance are carbon tetrachloride and cadmium. Carbon tetrachloride produces tolerance to itself by decreasing the formation of the reactive metabolite (trichloromethyl radical) that produces liver injury (Chap. 13). The mechanism of cadmium tolerance is explained by induction of metallothionein, a metal-binding protein. Subsequent binding of cadmium to metallothionein rather than to critical macromolecules thus decreases its toxicity. DOSE RESPONSE The characteristics of exposure and the spectrum of effects come together in a correlative relationship customarily referred to as the dose–response relationship.
Toxicology science of poisons by Curtis Klaassen
by Kenneth
4.5