Curtis Klaassen's Toxicology science of poisons PDF

By Curtis Klaassen

ISBN-10: 0071124535

ISBN-13: 9780071124539

ISBN-10: 0071347216

ISBN-13: 9780071347211

The such a lot relied on all-in-one review of the biomedical and environmental points of toxicology--NOW extra whole, updated, and in complete color

A Doody's center name for 2015!

NEW to the 8th Edition

  • FULL-COLOR layout to permit for a clearer interpretationof the fundamental elements of toxicology featured during the textual content
  • EXPANDED tables, illustrations, and different visuals areupdated with cutting-edge criteria that makes thisedition much more present and correct
  • DVD with picture financial institution gains all tables and illustrations from the textual content in presentation-ready structure
  • NEW CHAPTERS comprise "Toxic results of Calories"and "Toxic results of Nanoparticles"

The world's prime and so much authoritative textbook on poisons has extra to provide students,toxicologists, and pharmacologists than ever prior to. Now in complete colour, and punctiliously revised, the 8th version of Casarett & Doull's TOXICOLOGY: the elemental technological know-how of Poisons not just promises a finished overview of the basic parts of toxicology, it bargains the main up-to-date,revealing, and in-depth examine the systemic responses of poisonous substance on hand anywhere.

Combined with the newest considering via the field's most efficient students plus sturdy insurance of basic ideas, modes of motion, and chemical-specific toxicity, this landmark textual content keeps to set the normal for toxicology references.

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However, genetic polymorphism may have other important but less dramatic effects than those described for acute idiosyncratic responses (such as that occurring in pseudocholinesterase-deficient individuals after succinylcholine exposure). For example, it is recognized that approximately 50 percent of the Caucasian population has a gene deletion for the enzyme glutathione S-transferase M1. , those who lack both copies of the normal gene) are functionally and physiologically normal. However, epidemiologic studies have indicated that smokers who are homozygous for the null allele may be at slightly increased risk of developing lung cancer compared with smokers who have one or both copies of the normal gene (Houlston, 1999; Strange and Fryer, 1999).

Theoretically, if no cumulative effect occurs over the doses, the chronicity index will be 1. If a compound were absolutely cumulative, the chronicity index would be 90. Statistical procedures similar to those used to calculate the LD50 can also be used to determine the lethal time 50 (LT50), or the time required for half the animals to die (Litchfield, 1949). The LT50 value for a chemical indicates the time course of the toxic effects but does not indicate whether one chemical is more toxic than another.

Two chemicals known to produce dispositional tolerance are carbon tetrachloride and cadmium. Carbon tetrachloride produces tolerance to itself by decreasing the formation of the reactive metabolite (trichloromethyl radical) that produces liver injury (Chap. 13). The mechanism of cadmium tolerance is explained by induction of metallothionein, a metal-binding protein. Subsequent binding of cadmium to metallothionein rather than to critical macromolecules thus decreases its toxicity. DOSE RESPONSE The characteristics of exposure and the spectrum of effects come together in a correlative relationship customarily referred to as the dose–response relationship.

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Toxicology science of poisons by Curtis Klaassen

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