By K. Buerki (auth.), Gisela H. Degen, Jürg P. Seiler, Philip Bentley (eds.)
ISBN-10: 3642794513
ISBN-13: 9783642794513
ISBN-10: 364279453X
ISBN-13: 9783642794537
The quantity includes the most papers provided on the 1994 EUROTOX Congress, Basel, Switzerland, August 21-24, 1994. Toxicology has develop into a much less descriptive technological know-how simply because extra value has been put on the mechanisms underlying poisonous results. this is often mirrored in symposia and workshops dedicated to species changes in organ toxicity, receptor-mediated toxicity and stereochemical results of xenobiotics. contemporary growth within the fields of immunotoxicology, ecotoxicology, and neurotoxicology is highlighted and documented including the current dialogue on harmonized regulatory guidelines.
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Additional resources for Toxicology in Transition: Proceedings of the 1994 EUROTOX Congress Meeting Held in Basel, Switzerland, August 21–24, 1994
Example text
Health Physics, 57 Supplement 1): 405 - 409. M. and Hasselblad, V. (1992) Application of a Bayseian Statistical Approach to Response Analysis of Noncancer Toxic Effects. TheToxicologist, 12: 98. ILSI Report (1994). Report of the Benchmark Dose Workshop. International Life Sciences Institute. Risk Science Institute. C. R. (1993) Comparison of benchmark and NOAEL approaches in risk assessment of air toxics. The Toxicologist. 13: 142. Bioindicators in Ecotoxicology (Chair: Prof. Dr. J. Lopez-Barea, Spain) Biomarkers Overview in Ecotoxicology: an J.
For studies with data showing good dose-response relationship, there was less variability between the maximum likelihood estimate and the benchmark dose. Also for studies with good quantal dose-response data, the BMDos was in the same range as the NOAEL for a majority of the studies. For two studies, BMD 10 also approximated the NOAEL. A recent report recommending the use of BM05 or BMlO as a starting point for developing an RID value was in concert with our fmding (ILSI, 1994). For continuous data, there does not appear to be any consistent relationship between the NOAEL and the BMD values when mean values are compared.
3. 4. The mouse pronucleus is more accessible than the rat pronucleus. Embryonic stem cell cultures can only be produced in mice. Large gene libraries are available for mice, but not for rats. Short gestation time and large litter size facilitates the use of mice. From a toxicological perspective, rat models would be substantially more useful, as a larger body of toxicity data is available in the rat. Comparative risk assessments and mechanistic extrapolations could be more informative if results from rat transgenic models of carcinogenesis and mutagenesis were also available.
Toxicology in Transition: Proceedings of the 1994 EUROTOX Congress Meeting Held in Basel, Switzerland, August 21–24, 1994 by K. Buerki (auth.), Gisela H. Degen, Jürg P. Seiler, Philip Bentley (eds.)
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