New PDF release: The Comet Assay in Toxicology (Issues in Toxicology)

By Alok Dhawan, Diana Anderson, Mike D Waters, Tim Marrs, Andrew R Collins, Michael J Plewa, Tomas Gichner, Narendra P Singh, Declan J McKenna, S M Piperakis, Maria Dusinska, Emilio Rojas, Siegfreid Knasmuller, Giada Frenzilli, Sheena E.M. Lewis, Andreas

ISBN-10: 0854041990

ISBN-13: 9780854041992

The huge variety of chemical substances latest or being additional into the surroundings, have globally aroused nice situation concerning their hostile results in human inhabitants. improvement and validation of delicate and higher try platforms which could investigate the opposed results of chemical compounds at an early degree for intervention thoughts to be carried out in time is presently in growth. This ebook records the newest examine and showcases the flexible, cutting-edge approach - the Comet assay - within the box of recent toxicology. The assay is a straightforward, delicate swift and visible procedure for the quantitative and qualitative evaluation of DNA harm in unmarried cells. The Comet Assay in Toxicology is the 1st e-book of its type to be dedicated completely to the Comet assay and its functions as a big device in smooth toxicology. This multi-author booklet will function either a reference and a advisor to investigations within the biomedical, biochemical and pharmaceutical sciences. Written through investigators from the fields of genetic toxicology and human epidemiology, the authors have first-hand wisdom from their selected sub-specialities and are lively members to the peer-reviewed clinical literature. The publication is split into 5 significant sections, reflecting the variety of curiosity within the exploitation of this assay. The book's scope starts with an advent part reviewing its genesis for these new to the approach and the present wisdom of many of the fields during which it unearths extensive attractiveness. This part units the scene via explaining why the assay has develop into the main delicate and wanted assay in sleek toxicology. subsequent is a complete part that considers a variety of techniques being to evaluate varieties of DNA harm in quite a few mobilephone forms and is contributed by way of specialists within the respective fields. The 3rd part places jointly the explicit functions of the assay within the varied fields starting from genetic toxicity trying out to human tracking, and environmental toxicology. The fourth part includes the information and suggestions for the behavior of the assay in in vitro and in vivo structures, in line with the ideas of the overseas Workgroups on genotoxicity try out strategies. ultimately, the e-book attracts to an in depth with an evaluation of the data used for the knowledge of the knowledge generated through the assay.

Show description

Read Online or Download The Comet Assay in Toxicology (Issues in Toxicology) PDF

Similar toxicology books

New PDF release: Preclinical Development Handbook: Toxicology

A transparent, undemanding source to lead you thru preclinical drug developmentFollowing this book's step by step suggestions, you could effectively begin and whole severe stages of preclinical drug improvement. The publication serves as a basic,comprehensive connection with prioritizing and optimizing leads, toxicity, pharmacogenomics, modeling, and laws.

Download PDF by Michael Aschner, Lucio G. Costa: The Role of Glia in Neurotoxicity, Second Edition

Proposing the most recent learn in glial cellphone functionality gleaned from new strategies in imaging and molecular biology, The position of Glia in Neurotoxicity, moment version covers a number of elements of glial cells, together with morphology, body structure, pharmacology, biochemistry, pathology, and their involvement within the pathophysiology of neurological illnesses.

New PDF release: Veterinary Drug Residues. Food Safety

Content material: reliable animal husbandry perform and residues within the usa / Lester M. Crawford -- Human future health dangers linked to drug residues in animal-derived meals / S. F. Sundlof and J. Cooper -- buyer perceptions and issues approximately veterinary drug residues / Christine M. Bruhn -- eu Union regulatory residue research of veterinary medicines : a strategic technique / R.

Additional resources for The Comet Assay in Toxicology (Issues in Toxicology)

Example text

Menke, A. Meister and I. Schubert, N-Methyl-N-nitrosourea-induced DNA damage detected by the Comet assay in Vicia faba nuclei during all interphase stages is not restricted to chromatid aberration hot spots, Mutagenesis, 2000, 15(6), 503–6. 32 Chapter 1 22. T. Gichner and M. J. Plewa, Induction of somatic DNA damage as measured by single-cell gel electrophoresis and point mutation in leaves of tobacco plants, Mutat. , 1998, 401(1–2), 143–52. 23. G. Koppen, L. M. Toncelli, L. Triest and L. Verschaeve, The Comet assay: a tool to study alteration of DNA integrity in developing plant leaves, Mech.

Frenzilli, V. Scarcelli, S. Gorbi and F. Regoli, Induction of DNA-strand breakage and apoptosis in the eel Anguilla anguilla. Mar. Environ. , 2002, 54(3–5):517–20. 38 Chapter 1 95. G. Frenzilli, V. Scarcelli, I. Del Barga, M. Nigro, L. , DNA damage in eelpout (Zoarces viviparus) from Go¨teborg harbour. Mutat. Res. 2004, 552 (1–2), 187–95. 96. R. Gabbianelli, G. Lupidi, M. Villarini and G. Falcioni, DNA damage induced by copper on erythrocytes of gilthead sea bream Sparus aurata and mollusk Scapharca inaequivalvis, Arch.

De Freitas and J. ) erythrocytes for the detection of genotoxic pollutants in aquatic environment, Mutat. , 2004a, 560(1), 57–67. 82. V. M. deAndrade, J. Silva, F. R. Silva, V. D. Heuser, J. F. Dias and M. L. , Fish as bioindicators to assess the effects of pollution in two southern Brazilian rivers using the Comet assay and micronucleus test, Environ. Mol. , 2004b, 44(5), 459–68. The Comet Assay in Different Models 37 83. S. Sharma, N. S. Nagpure, R. Kumar, S. Pandey, S. K. Srivastava and P. J. , Studies on the genotoxicity of endosulfan in different tissues of fresh water fish Mystus vittatus using the Comet assay, Arch.

Download PDF sample

The Comet Assay in Toxicology (Issues in Toxicology) by Alok Dhawan, Diana Anderson, Mike D Waters, Tim Marrs, Andrew R Collins, Michael J Plewa, Tomas Gichner, Narendra P Singh, Declan J McKenna, S M Piperakis, Maria Dusinska, Emilio Rojas, Siegfreid Knasmuller, Giada Frenzilli, Sheena E.M. Lewis, Andreas

by Kevin

Rated 4.20 of 5 – based on 17 votes