By Alok Dhawan, Diana Anderson, Mike D Waters, Tim Marrs, Andrew R Collins, Michael J Plewa, Tomas Gichner, Narendra P Singh, Declan J McKenna, S M Piperakis, Maria Dusinska, Emilio Rojas, Siegfreid Knasmuller, Giada Frenzilli, Sheena E.M. Lewis, Andreas
The huge variety of chemical substances latest or being additional into the surroundings, have globally aroused nice situation concerning their hostile results in human inhabitants. improvement and validation of delicate and higher try platforms which could investigate the opposed results of chemical compounds at an early degree for intervention thoughts to be carried out in time is presently in growth. This ebook records the newest examine and showcases the flexible, cutting-edge approach - the Comet assay - within the box of recent toxicology. The assay is a straightforward, delicate swift and visible procedure for the quantitative and qualitative evaluation of DNA harm in unmarried cells. The Comet Assay in Toxicology is the 1st e-book of its type to be dedicated completely to the Comet assay and its functions as a big device in smooth toxicology. This multi-author booklet will function either a reference and a advisor to investigations within the biomedical, biochemical and pharmaceutical sciences. Written through investigators from the fields of genetic toxicology and human epidemiology, the authors have first-hand wisdom from their selected sub-specialities and are lively members to the peer-reviewed clinical literature. The publication is split into 5 significant sections, reflecting the variety of curiosity within the exploitation of this assay. The book's scope starts with an advent part reviewing its genesis for these new to the approach and the present wisdom of many of the fields during which it unearths extensive attractiveness. This part units the scene via explaining why the assay has develop into the main delicate and wanted assay in sleek toxicology. subsequent is a complete part that considers a variety of techniques being to evaluate varieties of DNA harm in quite a few mobilephone forms and is contributed by way of specialists within the respective fields. The 3rd part places jointly the explicit functions of the assay within the varied fields starting from genetic toxicity trying out to human tracking, and environmental toxicology. The fourth part includes the information and suggestions for the behavior of the assay in in vitro and in vivo structures, in line with the ideas of the overseas Workgroups on genotoxicity try out strategies. ultimately, the e-book attracts to an in depth with an evaluation of the data used for the knowledge of the knowledge generated through the assay.
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Additional resources for The Comet Assay in Toxicology (Issues in Toxicology)
Menke, A. Meister and I. Schubert, N-Methyl-N-nitrosourea-induced DNA damage detected by the Comet assay in Vicia faba nuclei during all interphase stages is not restricted to chromatid aberration hot spots, Mutagenesis, 2000, 15(6), 503–6. 32 Chapter 1 22. T. Gichner and M. J. Plewa, Induction of somatic DNA damage as measured by single-cell gel electrophoresis and point mutation in leaves of tobacco plants, Mutat. , 1998, 401(1–2), 143–52. 23. G. Koppen, L. M. Toncelli, L. Triest and L. Verschaeve, The Comet assay: a tool to study alteration of DNA integrity in developing plant leaves, Mech.
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The Comet Assay in Toxicology (Issues in Toxicology) by Alok Dhawan, Diana Anderson, Mike D Waters, Tim Marrs, Andrew R Collins, Michael J Plewa, Tomas Gichner, Narendra P Singh, Declan J McKenna, S M Piperakis, Maria Dusinska, Emilio Rojas, Siegfreid Knasmuller, Giada Frenzilli, Sheena E.M. Lewis, Andreas