By Andreas Luch (Editor)
This booklet presents an summary at the molecular mode of motion of carcinogenic polycyclic fragrant hydrocarbons (PAHs). PAHs are by-products bobbing up from incomplete combustion of natural subject which are often published into our surroundings, and hence are ubiquitously detectable. Many PAHs are robust cancer agents in rodent bioassays and feature been associated with elevated incidences of varied different types of melanoma in people. the current booklet covers all points of PAH-induced carcinogenesis; it's a number of articles written by means of the most recognizable PAH researchers, reviewing the current wisdom during this box. the themes contain: publicity to and biomonitoring of PAHs within the human inhabitants; metabolic activation of PAHs; genotoxicity and service of PAH-induced DNA harm; and components modulating person susceptibility to the deleterious results of PAHs.
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Additional resources for The Carcinogenic Effects of Polycyclic Aromatic Hydrocarbons
Particularly strong evidence was collected for the sterically hindered bay-region PAHs 5-MeC193"195 and DMBA,196"198 as well as for the fjord-region PAH DB[a,/]P199-201 (cf. 6). 203 Only some minor products were found to arise from diastereomeric syn-diol-epoxides or from reactions at different positions in nucleobases. 6) withN 6 -dA. I 4 7 J " Based on the exceptionally high reactivity of the strong carcinogen DMBA at N6-dA residues in DNA it had been already anticipated in 1983 by Dipple and colleagues that PAH-N6-dA adducts might have the greater potency for tumor induction as o (+>anft'-B[a]PDE-10- ?
Med. J. 22:135-137. 4. Henry S A (1947) Occupational cutaneous cancer attributable to certain chemicals in industry. Br. Med. Bull. 4: 389-401. 5. Yamagiwa K and Ichikawa K (1915) Experimentelle Studie ilber die Pathogenese der Epifhelialgeschwulste. Mitt. Med. Fak. Kaiserl. Univ. Tokio 15: 295-344. 6. /. Cancer Res. 3: 1-29. 7. Tsutsui H (1918) Uber das kiinstlich erzeugte Cancroid bei der Maus. Gann 12: 17-21. 8. Passey RD (1922) Experimental soot cancer. Br. Med. J. 2: 1112-1113. 9. Bloch B and Dreifuss W (1921) Ueber die experimentelle Erzeugung von Carcinomen mit Lymphdrusen- und Lungenmetastasen durch Teerbestandteile.
In contrast to these theoretical assumptions however, the (—)-7,8-dihydrodiol of B[a]P is preferentially converted to the (+)-anti-7R,SS-diol-9S,10R-epoxide [(+)-anti-B[a]PDE]. 5). 10 ' 173 ' 179 Considering the high enantioselectivity during formation of the trans-dihydrodiols and the diastereoselectivity during formation of the diol-epoxides, the main product in bay-region metabolism of B[a]P catalyzed by rat liver microsomes appears to be (+)-anti-B[a]PDE. In contrast, the three other diastereomeric diolepoxides are only formed in minor amounts.
The Carcinogenic Effects of Polycyclic Aromatic Hydrocarbons by Andreas Luch (Editor)