By T. W. Clarkson, G. F. Nordberg, P. R. Sager, M. Berlin, L. Friberg, D. R. Mattison (auth.), Thomas W. Clarkson, Gunnar F. Nordberg, Polly R. Sager (eds.)
ISBN-10: 1461593468
ISBN-13: 9781461593461
ISBN-10: 1461593484
ISBN-13: 9781461593485
The everlasting fee and foreign organization on Occupational future health (PCIAOH) confirmed in 1969 a Subcommittee at the Toxicology of Metals less than the chairmanship of Lars Friberg. This committee, which later was once named the medical Committee at the Toxicology of Metals, has geared up a few past conferences that experience resulted in courses in 3 significant components of steel toxicology: a initial assembly in Slanchev Bryag, Bulgaria in- 1971, by way of a gathering in 1972 in Buenos Aires, Argentina which produced experiences (Dukes and Friberg, 1971; job workforce on steel Accumulation, 1973), that mentioned the metabolism of metals with precise connection with absorption, excretion and organic half-times. the results and dose-response relationships of poisonous metals, together with a dialogue of basic rules, was once the second one significant subject addressed through the clinical Committee at a gathering in Tokyo in 1974 (Nordberg, 1976). The philosophy of this convention, in addition to the former one in Buenos Aires, used to be in accordance with the concept that of a "threshold dose" for the incidence of difficult results. In a convention held in Atlanta, united states in 1980, the scope of dialogue on steel results was once broadened to incorporate the function of metals in carcinogenesis. hence, for the 1st time, the medical Committee took into consideration the potential of non-threshold relationships (Belman and Nordberg, 1981). furthermore, the clinical Committee at the Toxicology of Metals geared up a workshop on steel interactions in Stockholm 1977 (Nordberg et al.
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41 44 60 62 78 REPRODUCTIVE AND DEVELOPMENTAL TOXICITY OF METALS; FEMALE REPRODUCTIVE SYSTEM Donald R. Mattison,l Allen H. J. Copius Peereboom-Stegeman 6 lpregnancy Research Branch National Institute of Child Health and Human Development Bethesda, Maryland 2Division of Genetics and Toxicology University of Rochester, Rochester, New York 3Department of Radiation Biology 4C. N. -So C. K. Institute of Zoology SUniversity of Uppsala, Uppsala, Sweden Institute of Occupational Health Helsinki, Finland 6Laboratory of Histology and Cell Biology University of Amsterdam, Amsterdam, Holland INTRODUCTION In the female, reproduction is a continuous process beginning with the development of the reproductive organs prenatally, continuing through sexual maturation and extending to the time of reproductive scenescence.
No human data are available on levels in milk after exposure to mercuric or elemental mercury, although animal data indicate inorganic mercury is accumulated in the mammary gland. Information on the metabolism of mercury in the suckling infant or lactating mother is sparse. The lactating mother generally has a significantly shorter half-time (about 40 days) in blood than the non-lactating female {half-time about 50 days). Experimental studies indicate that the suckling infant excretes mercury at a very low rate after exposure to methyl or inorganic mercury.
41 44 60 62 78 REPRODUCTIVE AND DEVELOPMENTAL TOXICITY OF METALS; FEMALE REPRODUCTIVE SYSTEM Donald R. Mattison,l Allen H. J. Copius Peereboom-Stegeman 6 lpregnancy Research Branch National Institute of Child Health and Human Development Bethesda, Maryland 2Division of Genetics and Toxicology University of Rochester, Rochester, New York 3Department of Radiation Biology 4C. N. -So C. K. Institute of Zoology SUniversity of Uppsala, Uppsala, Sweden Institute of Occupational Health Helsinki, Finland 6Laboratory of Histology and Cell Biology University of Amsterdam, Amsterdam, Holland INTRODUCTION In the female, reproduction is a continuous process beginning with the development of the reproductive organs prenatally, continuing through sexual maturation and extending to the time of reproductive scenescence.
Reproductive and Developmental Toxicity of Metals by T. W. Clarkson, G. F. Nordberg, P. R. Sager, M. Berlin, L. Friberg, D. R. Mattison (auth.), Thomas W. Clarkson, Gunnar F. Nordberg, Polly R. Sager (eds.)
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