Renal cell carcinoma : molecular biology, immunology, and by Ronald M Bukowski; Andrew C Novick PDF

By Ronald M Bukowski; Andrew C Novick

ISBN-10: 0896037819

ISBN-13: 9780896037816

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J. , 91 (1995) 167–168. Chapter 3 / Immunologic Response to RCC 3 39 Immunologic Response to Renal Cell Carcinoma James H. Finke, Lisa Salvucci Kierstead, Elena Ranieri, and Walter J. Storkus CONTENTS CELLULAR IMMUNITY TO RCC LOCOREGIONAL IMMUNOCOMPETENCE AND TH1/TC1 VS TH2/TC2 ANTI-RCC T-CELL-MEDIATED IMMUNITY INDUCTION OF ANTI-RCC T-CELL IMMUNITY CHARACTERIZATION OF CELLULAR IMMUNE RESPONSE TO RCC IDENTIFICATION OF RCC-ASSOCIATED CD8+ T-CELL-DEFINED ANTIGENS AND EPITOPES IDENTIFICATION OF RCC-ASSOCIATED CD4+ T-CELL-DEFINED ANTIGENS AND EPITOPES ACTIVE IMMUNOTHERAPY OF RCC: VACCINES DC-BASED VACCINES: CROSS-PRESENTATION AND “EPITOPE S PREADING” FUTURE DIRECTIONS SUMMARY ACKNOWLEDGMENTS REFERENCES 1.

1 (1991) 41–52. 44. Licht MR, Novick AC, Tubbs RR, Klein EA, Levin HS, and Streem SS. Renal oncocytoma: clinical and biological correlates, J. , 150 (1993) 1380–1383. 45. Wang YE, Song HZ, Yang XY, Dong SY, and Gan N. Renal metastases of choriocarcinoma. A clinicopathological study of 31 cases, Chinese Med. , 104 (1991) 716-720. 46. Volpe JP and Choyke PL. The radiologic evaluation of renal metastases. Critical reviews in diagnostic imaging, Crit. Rev. Diagn. Imaging, 30 (1990) 219–246. 47. Ferry JA, Harris NL, Papanicolaou N, and Young RH.

In general, the ability of an organism to mount a Th1-biased immune response has been affiliated with enhanced ability to eliminate certain pathogens and tumors (35,36). IL-12 (produced by dendritic cells, [37]), in particular, appears to play an important role in determining whether a Th1- or Th2-biased immune response is mounted to antigenic challenge. Functionally, IL-12 has been demonstrated to bias the immune response toward a Th1 phenotype in vitro and in vivo (38). In addition to promoting Th1 development from naive and memory T-cell populations, IL-12 has also been shown to suppress the development of Th2 cells (39,40).

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Renal cell carcinoma : molecular biology, immunology, and clinical management by Ronald M Bukowski; Andrew C Novick


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