By Christoph Stippich MD (auth.), C. Stippich MD (eds.)
Functional magnetic resonance imaging (fMRI) has contributed considerably to development in neuroscience through allowing noninvasive imaging of the "human mind at paintings" less than physiological stipulations. inside of scientific neuroimaging, fMRI is starting up a brand new diagnostic box by way of measuring and visualizing mind functionality. even if, fMRI isn't really but a customary diagnostic imaging procedure.
This textbook is dedicated to preoperative fMRI in sufferers with mind tumors and epilepsies, that are the main well-established medical functions. via localizing and lateralizing particular mind features in person sufferers, in addition to epileptogenic zones, fMRI enables the choice of a secure therapy and the making plans and function of function-preserving neurosurgery.
State of the paintings fMRI strategies are awarded, with unique attention of useful points, imaging and information processing, general and pathological findings, and diagnostic percentages and obstacles. The appropriate info on mind body structure, sensible neuroanatomy, imaging strategy, and method is supplied by means of well-known specialists in those fields. additional chapters deal with the validity of presurgical practical localization, multimodality useful neuroimaging, mind plasticity, and pitfalls, suggestions, and tips. The e-book is designed to be of price to newbies, proficient clinicians and specialists alike.
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Sensible magnetic resonance imaging (fMRI) has contributed considerably to development in neuroscience by means of allowing noninvasive imaging of the "human mind at paintings" less than physiological stipulations. inside medical neuroimaging, fMRI is beginning up a brand new diagnostic box by way of measuring and visualizing mind functionality.
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Additional info for Clinical Functional MRI: Presurgical Functional Neuroimaging
Designs with short temporal intervals between trials are called rapid event-related designs (Fig. 10). While the measured response of rapid event-related designs will contain a combination of overlapping responses from closely spaced trials, condition-speciﬁc event-related time courses can be isolated using deconvolution analysis. Deconvolution analysis works correctly only under the assumption of a linear system (see Sect. 2) and requires randomized intertrial intervals (“jitter”), which can be easily obtained by adding “null” (baseline) trials when trial sequences are created for an experiment.
Mean differences) in data samples. g. 05), one rejects the null hypothesis and accepts the alternative hypothesis stating that there exists a true effect. Note that the decision to accept or reject b Fig. 14a,b. Principle of statistical data analysis. An experiment with two conditions (“Stim” and “Rest”) has been performed. a Time course obtained in area 1. b Time course obtained in area 2. Calculation and subtraction of Mean 1 (“Rest” condition) from Mean 2 (“Stim” condition) leads to the same result in (a) and (b).
During fMRI measurements, a set of slices, often covering the whole brain, is scanned repeatedly over time. Although the repeated slice measurements look almost identical, small task-related signal ﬂuctuations may occur at different brain regions at different moments in time (a). To visualize these subtle ﬂuctuations, the time course of any desired brain region may be depicted (b). The smallest separate brain region one can select to display a time course in a two-dimensional image (slice) is called pixel (picture element) while the smallest region in a three dimensional “image” is called voxel (volume element).
Clinical Functional MRI: Presurgical Functional Neuroimaging by Christoph Stippich MD (auth.), C. Stippich MD (eds.)