Regulation of Macromolecular Synthesis by Low Molecular - download pdf or read online

By Gebhard Koch

ISBN-10: 0124175805

ISBN-13: 9780124175808

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Extra resources for Regulation of Macromolecular Synthesis by Low Molecular Weight Mediators

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The effects of ppGpp on translational specificity, and the theoretical explanation we have advanced, raise an interesting implication in this age of rapid jet travel, rapid media communication, rapid scientific publication, and rapid everything 21 Stringent Control of Translational Accuracy else. It is that, in some circumstances at least, slower can be better, or at least perfectly all right. The scientific literature itself is not without some embarrassing examples of the trade-off between speed and precision.

Loftfield, R. B. (1963). The Frequency of Errors in Protein Synthesis. Biochem. J. 89:2-85. Loftfield, R. B. and Vanderjagt, D. (1972). The Frequency of Errors in Protein Biosynthesis. Biochem. J. 128:13531356. Ninio, J. (1974). A Semi-quantitative Treatment of Missense and Nonsense Suppression in the strA and ram Ribosomal Mutants of E. coli. J. Mol. Biol. 54:297-313. Ninio, J. (1975). Kinetic Amplification of Enzyme Discrimination. Biochimie 57:587-595. Ninio, J. (1975). La Precision dans la Traduction Génétique.

Nevertheless the biochemical phenotype of the mutant is fairly convincing in demonstrating a complete deficiency of ppGpp accumulation. The inability to accumulate ppGpp during a carbon source starvation is certainly unique among E. coli strains we have studied. We would like to interpret mutant growth in the absence of ppGpp as indicating that ppGpp is a dispensable metabolite and provides no essential functions under steady-state growth conditions. Nevertheless, relS strains do grow more slowly than relS+ strains in minimal media and are less able to adjust to downshifts of amino acid availability.

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Regulation of Macromolecular Synthesis by Low Molecular Weight Mediators by Gebhard Koch

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