Download e-book for kindle: Principles and Methods of Toxicology, Fifth Edition by A. Wallace Hayes

By A. Wallace Hayes

ISBN-10: 084933778X

ISBN-13: 9780849337789

Based at the paradox that every one issues are poisons and the adaptation among poison and treatment is volume, the selection of secure dosage kinds the bottom and concentration of contemporary toxicology. with a view to make a legitimate selection there has to be a operating wisdom of the biologic mechanisms concerned and of the equipment hired to outline those mechanisms. whereas the vastness of the sphere and the quick accumulation of information may possibly avoid the potential of soaking up and holding greater than a fragment of the to be had info, a superb figuring out of the underlying ideas is essential.

Extensively revised and up-to-date with 4 new chapters and an multiplied word list, this 5th variation of the vintage textual content, rules and techniques of Toxicology offers complete assurance in a attainable and obtainable structure. New themes comprise 'toxicopanomics', plant and animal poisons, details assets, and non-animal trying out possible choices. Emphasizing the cornerstones of toxicology-people range, dose concerns, and issues switch, the publication starts with a evaluation of the heritage of toxicology and through a proof of easy toxicological ideas, brokers that reason toxicity, objective organ toxicity, and toxicological trying out tools together with the various try protocols required to satisfy regulatory wishes around the world. The publication examines every one procedure or method from the perspective of approach and interpretation of information and discusses difficulties and pitfalls that could be linked to each one. The addition of a number of new authors permit for a broader and extra diversified therapy of the ever-changing and increasing box of toxicology.

Maintaining the top of the range info and organizational framework that made the former versions such a success, rules and techniques of Toxicology, 5th variation remains to be a worthy source for the complex practitioner in addition to the recent disciple of toxicology.

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Extra info for Principles and Methods of Toxicology, Fifth Edition

Example text

He also noted the increased sensitivity of children to some chemicals. The sweeps were usually children who worked from age 8 to adulthood, although apprenticeships could begin at age 4. Pott noted that this was an occupational disease and postulated that the cancer was caused by an ingredient in the residue from the burning coal. Pott’s pio- Principles and Methods of Toxicology, Fifth Edition neering work resulted in the Chimney-Sweepers Act of 1788, the year of his death. With the Industrial Revolution, which occurred between 1760 and 1830, workers no longer owned the means of production.

This classic work, the first of its kind, effectively combined forensic and clinical toxicology with analytical chemistry. It is a vast mine of experimental observation on the symptoms of poisoning of all kinds, on the effects poisons have in the body, on their physiological action, and on the means of detecting them. It earned Orfila the title of father of forensic toxicology. It is the first book devoted entirely to toxicology and established toxicology as an experimental science separate from pharmacology.

It is said that she was responsible for the deaths of many thousands. La Voisin was burned at the stake. Throughout time woman have taken a particular interest in poison for criminal purposes, and the extent of this can be seen in an account from Rome in 1659. A society of women was formed in secret, meeting regularly at the house of a reputed witch, Hieronyma Spara. Usually married, the members of this society were issued the poison they required with instructions for its use. Spara was eventually arrested by the Papal police and tortured on the rack.

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Principles and Methods of Toxicology, Fifth Edition by A. Wallace Hayes

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