By Peter J. Tarcha
ISBN-10: 0849356520
ISBN-13: 9780849356520
Polymers for managed Drug supply addresses the demanding situations of designing macromolecules that carry healing brokers that functionality correctly and in live performance with residing organisms. The e-book essentially discusses periods of polymers and polymeric cars, together with particulates, equivalent to latexes, coacervates, ion-exchange resins, and liposomes, in addition to non-particulate automobiles similar to enteric coatings, mediators, and bioadhesives. different issues mentioned comprise diffusion; biodegradation-controlled supply; animal version stories for toxicity, metabolism, and removing trying out; and FDA requisites for scientific stories. Drug supply researchers will locate this e-book to be a useful reference software.
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Extra info for Polymers for Controlled Drug Delivery
Sample text
Evaluation of Enteric Coatings ................................................... 61 A. In Vitro Methods ......................................................... 61 B. - In Vivo Methods.......................................................... 62 VIII. Recent Advances and Future of Enteric Coatings ................................ 63 References............................................................................... 64 40 Polymers for Controlled Drug Delivery I. DEFINITION AND HISTORY An enteric coating is one that resists disintegration or dissolution in gastric media, but disintegrates or dissolves in intestinal fluids.
Polym. , 17, 3779, 1973. 10. Ratner, B. , Hydrogel surfaces, in Hydrogels in Medicine and Pharmacy, Peppas, N. , CRC Press, Boca Raton, FL, 1986. 11. Holly, F. J. and Refojo,M. , Water wettability of hydrogels. I. Poly(2-hydroxyethyl methacrylate), J. Biomed. Mater. , 9, 315, 1975. 12. , Protein adsorption to hydrogels, in Hydrogels in Medicine and Pharmacy, Peppas, N. , CRC Press, Boca Raton, FL, 1986. 13. , Olf, H. , Lamaze, C. , Movement of water in homogeneous water-swollen polymers, in Water Structure at the Water-Polymer Interface, Jellinek, H.
8• The wider range of behavior that can be 4 49 28 Polymers for Controlled Drug Delivery 100 time FIGURE 3. Qualitative drug release behavior of swollen gels (I); swellable gels (2); and swelling-controlled gels (3). 50 The qualitative drug release behavior of swollen hydrogels, swellable hydrogels, and swelling controlled hydrogels is illustrated in Figure 3. VI. SOME IMPORTANT HYDROGEL POLYMERS This section outlines the properties of some of the prominent hydrogel homopolymers as well as a few selected copolymers.
Polymers for Controlled Drug Delivery by Peter J. Tarcha
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