Download e-book for iPad: Platelet-Vessel Wall Interactions by Ian J. Mackie, Christopher R. Neal (auth.), R. Michael

By Ian J. Mackie, Christopher R. Neal (auth.), R. Michael Pittilo BSc, PhD, CBiol, MIBiol, Samuel J. Machin MRCPath (eds.)

ISBN-10: 1447114558

ISBN-13: 9781447114550

ISBN-10: 1447114574

ISBN-13: 9781447114574

The booklet of Platelet-Vessel Wall Interactions, the second one monograph within the Bloomsbury sequence in medical technological know-how, is particu­ larly welcome as its visual appeal indicates the extra improvement of the sequence and its capability for the long run. The subject matter of this monograph is the pathophysiology of atherosclerosis, a subject matter that symbolises the purpose of the sequence, particularly to spotlight the $64000 interfaces among easy clinical technology and scientific perform. Our congratulations to the Editors and participants. London, December 1987 lack Tinker Preface within the Western global, atherosclerosis reasons extra disease and loss of life than the other affliction. regardless of its devastating results, the pathogenesis of the illness continues to be a question for speculation and con­ jecture. This monograph owes its notion to a programme of labor directed in the direction of realizing the elemental pathophysiology of atherosclerosis. The circulatory process is coated by means of vascular endothelium which has a relevant position in holding the integrity of the vessel wall and stop­ ing thrombosis. The typical equilibrium latest among general en­ dothelium which helps blood stream, and platelets which serve to re­ pair broken endothelium, is explored within the first chapters. Atherosclerosis constructing as a reaction to endothelial harm is one speculation which has inspired frequent curiosity, and re­ seek has principally been directed in the direction of discovering the injurious agent.

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Proc Natl Acad Sci USA 74: 4033-4036 Miletich JP, Jackson CM, Majerus PW (1978a) Patients of the factor Xa binding site on human platelets. J Bioi Chern 253: 6908-6916 Miletich JP, Majerus OW, Majerus PW (1978b) Patients with congenital factor V deficiency have decreased factor Xa binding sites on their platelets. J C1in Invest 62: 824--831 Miller OV, Johnson RA, Gorman RR (1977) Inhibition of PGE1-stimulated cAMP accumulation in human platelets by thromboxane A 2• Prostaglandins 13: 599-609 Mosher DF (1980) Fibronectin.

Thromb Haemost 45: 173-179 Lahav J, Schwartz MA, Hynes RO (1982) Analysis of platelet adhesion with radioactive chemical crosslinking reagent: interaction of thrombospondin with fibronectin and collagen. Cell 31 : 253-262 Lahav J, Lawler J, Gimbrone M (1983) Analysis of the interaction of thrombospondin with fibronectin, fibrinogen and thrombospondin. Thromb Haemost 50: 85 Lawler J, Simons ER (1983) The effect of calcium on the circular dichroism and limited tryptic digestion of thrombospondin.

Furthermore, the endothelium is responsible for the control of vascular permeability. Some consideration will now be given to the morphology, and to a lesser extent the functional aspects, of endothelium. Endothelial Folds When examined both by light and electron microscopy, the arterial endothelium typically has a scalloped morphology. This has appeared as folds when the endothelial surface has been examined by scanning electron microscopy (Groniowski et al. 1971; Kawamura et al. 1974a; Shimamoto 1969; Shimamoto et al.

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Platelet-Vessel Wall Interactions by Ian J. Mackie, Christopher R. Neal (auth.), R. Michael Pittilo BSc, PhD, CBiol, MIBiol, Samuel J. Machin MRCPath (eds.)

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