Download PDF by D. Schiffer (auth.), P. Paoletti, K. Takakura, M. D. Walker,: Neuro-Oncology

By D. Schiffer (auth.), P. Paoletti, K. Takakura, M. D. Walker, G. Butti, S. Pezzotta (eds.)

ISBN-10: 9401053901

ISBN-13: 9789401053907

ISBN-10: 940113152X

ISBN-13: 9789401131520

This quantity comprises the court cases of the newest in a sequence of foreign symposia on advances in neuro-oncology, held September 26-29, 1990, in San Remo, Italy and backed through the collage of Pavia, I.R.C.C.S. Policlinico San Matteo (Pavia, Italy) and the Giovanni Lorenzini scientific beginning (Milan-Houston). It drew papers from six continents of the area, was once attended by way of over 500 investigators, and proven the intense energy, intensity and breadth of study which characterizes modem neuro-oncology. Over the process the decade, there was a extraordinary shift in learn performed within the heterogeneous box of neuro-oncology, which seems to be clear of scientific descriptive experiences, and towards extra easy and basic research of the pathology, immunohis tochemistry, biochemical and mobile subsets of mind tumors. in addition to the normal fields of neurology, neurosurgery, neuropathology, and radiation treatment, there was an elevated curiosity and involvement via investigators within the fields of clinical oncology, neuroradiology, immunology, and plenty of parts of primary neurobiology. It has develop into glaring that curiosity has additionally been exhibited in a broader spectrum of tumors than simply the malignant glial sequence, and experiences in meningioma, craniopharyngioma, neurinomas, and the pituitary tumors have been pronounced. a number of periods have been dedicated to the distinctive difficulties of pediatric mind tumors.

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Neuron 1:175-182 Hinton DR (1990) Morphologic and biochemical analysis of the antigen defined by antibody Ki-67. J Neuropathol Exp Neuro149:321 (abstract) Hirota N, Veda M, Ozawa S, Abe 0, Shimizu N (1989) Suppression of an epidermal growth factor receptor-hyperproducing tumor by an immuntoxin conjugate of gelonin and a monoclonal anti-epidermal growth factor receptor antibody. Cancer Res 49:7106-7109 Hoshino T (1987) Proliferative potential of pediatric brain tumors. Prog Exp Tumor Res 30:3143 a a a 18 Hoshino T, Nagashima T, Cho KG, Murovic JA, Hodes IE, Wilson CB, Edwards MSB, Pitts LH (1986a) S-phase fraction of human brain tumors in situ measured by uptake of bromodeoxyuridine.

1989). 22) of low-grade gliomas contained EGFr positive glioma cells. The majority of meningiomas (16/18) was weakly EGFr positive. In the neurinoma group 6 benign neurinomas were EGFr negative while one anaplastic recurrent neurinoma was strongly labeled. Our results demonstrate that in gliomas and neurinomas the expression of EGFr is associated with advanced grades of malignancy. From the diagnostic point of view, immunohistochemistry for EGFr may therefore reveal additional information on the biological behaviour of gliomas and neurinomas.

This timing is very critical because chromosome analyses performed during this interval contain only first division cells, thereby eliminating artifacts that can arise from in vitro culturing [2). For the present studies, second and third aliquots of tumor cells were simultaneously subjected to two treatment protocols using the chemotherapeutic agent, BCNU. Protocol-l was designed to obtain clones resistant to pharmacologically achievable concentrations of drug utilizing a colony forming assay [10).

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