By Harold P. Morris, Lynnard J. Slaughter (auth.), Harold P. Morris, Wayne E. Criss (eds.)
In 1960, Dr. Van R. Potter and Dr. Henry Pitot (at McCardle Laboratory in Madison, Wisconsin), Dr. Tetsuo Ono (then at McCardle Laboratory and now on the eastern origin for melanoma learn in Tokyo, Japan) and Dr. Harold P. Morris (then on the nationwide melanoma Institute and now at Howard college, Washington, D. C. ) determined that an experimental melanoma version will be a useful instrument to check neoplastic alterations in cells. on the grounds that they have been examine ing a number of the hugely particular metabolic methods that are special to liver tissues, they made up our minds transplantable liver melanoma version may be the excellent method to paintings with. the program would supply for comparability of standard liver tissue of the non-tumor endure ing animal, the tumor bearing animal's (host) liver and the liver melanoma. Dr. Morris undertook a sequence of rat reviews making use of numerous chemical substances identified to reason liver melanoma. quickly the 1st Morris hepatomas (#3683, 3924A, 5123) have been being studied via a number of labs. throughout the subsequent 18 years, Dr. Morris constructed and transplanted a variety of traces of hepatomas of which no have been exact. those tumors ranged from the very slowly-growing, hugely differentiated melanoma tissues, e. g. , 96l8A that is a diploid tumor containing gly cogen and a "nearly common" supplement of enzymes, to a wide workforce of rapidly-growing, poorly differentiated melanoma tissues, e. g.
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Morris Hepatomas: Mechanisms of Regulation by Harold P. Morris, Lynnard J. Slaughter (auth.), Harold P. Morris, Wayne E. Criss (eds.)