By Mari S. Golub
Environmental endocrine disruptors were on the middle of discussions approximately chemical substances and their results on fertility, however the concentration has been on natural compounds and the function of metals has been principally neglected - beforehand. Taking an organ-system-based method, Metals, Fertility, and Reproductive Toxicity examines the consequences of metals present in the typical surroundings on fertility charges in people and animal populations. This quantity summarizes and evaluates the literature within the zone of steel results on fertility and copy in people, laboratory animals, and natural world. foreign specialists have contributed chapters that discover how the ovary, testes, uterine process, and neuroendocrine approach, between others, reply to steel publicity. Reviewing either present wisdom and leading edge facts, the chapters specialise in both a selected steel or a specific inhabitants. a tremendous volume of knowledge in this topic has been generated, summarized, and reviewed through the years. whereas there are lots of books on hand on metals toxicity and on reproductive toxicity, no present booklet explores either within the related quantity. Culling details from through the literature, Metals, Fertility, and Reproductive Toxicity provides an in-depth examine the function of metals in endocrine disruption and the spectrum of mechanisms related to metals which can impression replica.
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Additional resources for Metals, Fertility, and Reproductive Toxicity
3 mg/kg Days 0–7 of pregnancy Gavage Decreased pregnancy rate, decreased fetal wt. 5 mg/kg Days 0–3 of pregnancy Gavage Decreased pregnancy rate, decreased fetal wt. 2 mg/kg Days 0–3 or 4–7 of Gavage Decreased pregnancy rate, pre- and pregnancy postimplantation loss, decreased fetal wt. 2 mg/kg Days 0–3 or 4–7 of Gavage Suppression of uterine decidualization, pseudopregnancy decreased levels of serum progesterone 903 mg/kg Days 0–3 or 4–7 of Gavage Decreased fetal wt. 3 Reproductive Toxicity of Butyltin Compounds 36 Metals, Fertility, and Reproductive Toxicity Chapter 3: Reproductive and Developmental Toxicity 37 throughout the premating, mating, gestation, and lactation periods, for two generations.
TBT exposure to Japanese medaka at 1 mg/kg body weight caused a reduction of the spawning frequency (Nirmala et al. 1999). 3 ng/L for 21 days), and decreased sperm motility at concentrations less than 1 μg/L (Haubruge et al. 2000, Kime et al. 2001). Effects on Other Organisms Despite a great number of studies on imposex in snails and a comparable number of toxicity reports on fish, there is little information on development and reproductive effects on other species by organotin compounds. It was reported that imposex has not only been found in gastropods, but also been induced in Japanese freshwater crabs by TBT (Takahashi et al.
Arsenic-induced congenital malformations in genetically susceptible folate binding protein-2 knockout mice. Toxicol Appl Pharmacol, 177, 238–46. N. 2003. Arsenic in drinking water and adverse pregnancy outcome in an arseniasis-endemic area in northeastern Taiwan. Environ Res, 91, 29–34. D. 1977. Effect of metal ions on the binding of 17beta-estradiol to human endometrial cytosol. Fertil Steril, 28, 459–63. 55 Introduction Organotin compounds are chemicals widely used in agriculture and industry (Piver 1973, World Health Organization 1980).
Metals, Fertility, and Reproductive Toxicity by Mari S. Golub