By National Research Council, Division on Earth and Life Studies, Nuclear and Radiation Studies Board, Committee on Medical Isotope Production Without Highly Enriched Uranium
This e-book is the made from a congressionally mandated research to ascertain the feasibility of disposing of using hugely enriched uranium (HEU2) in reactor gasoline, reactor objectives, and clinical isotope creation amenities. The booklet focuses totally on using HEU for the creation of the clinical isotope molybdenum-99 (Mo-99), whose decay product, technetium-99m3 (Tc-99m), is utilized in nearly all of clinical diagnostic imaging approaches within the usa, and secondarily at the use of HEU for learn and try out reactor gasoline. the provision of Mo-99 within the U.S. may be unreliable until eventually more recent construction assets come on-line. The reliability of the present offer process is a crucial scientific isotope trouble; this e-book concludes that reaching a value distinction of under 10 percentage in amenities that might have to convert from HEU- to LEU-based Mo-99 creation is far less significant than is reliability of provide.
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Extra info for Medical Isotope Production Without Highly Enriched Uranium
An interruption at any point in the production, transport, or delivery of Mo-99 or technetium generators can have substantial impacts on patient care, as discussed in Chapter 4. Mo-99 PRODUCTION PROCESS There are two primary approaches for producing the medical isotope Mo-99, as described in Appendix D: fission of U-235, which produces Mo-99 and other medically important isotopes such as I-131 and Xe-133, and neutron capture by Mo-98 to produce Mo-99. S. or global demand for Mo-99. None of the four global producers of Mo-99 (Chapter 1) use the neutron capture method to produce Mo-99 because of its inefficiencies.
S. market through MDS Nordion and Mallinckrodt. It has been producing Mo-99 since 1979 at its site near Fleurus, Belgium. HEU targets are irradiated in three reactors: HFR, BR2, and Osiris. The irradiated targets are transported in shielded casks on trucks to the IRE facility for processing. IRE has a dedicated bank of hot cells for target processing, a backup set of processing hot cells, and a third set of hot cells that are used intermittently for processing of strontium. pdf. IRE also utilized a fourth reactor in Germany (FRJ-2) until it was shut down in 2006.
Market using a 5 MWt (megawatt thermal) research reactor located in Tuxedo, New York. This reactor was shut down when tritium contamination of surface waters adjacent to the reactor site was confirmed. A decision to decommission the reactor was subsequently made after a risk-benefit study carried out by Cintichem’s parent company, Hoffman-LaRoche, determined that its continued operation was not justified. S. technetium generator manu facturers (Amersham [now GE Healthcare], Mallinckrodt, and DuPont).
Medical Isotope Production Without Highly Enriched Uranium by National Research Council, Division on Earth and Life Studies, Nuclear and Radiation Studies Board, Committee on Medical Isotope Production Without Highly Enriched Uranium