By Diana Anderson, Martin H. Brinkworth
ISBN-10: 0854048472
ISBN-13: 9780854048472
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Extra resources for Male-mediated Developmental Toxicity Issues in Toxicology
Example text
5 describes the main findings of these three Nordic settings, focusing on the sibling study. 3 Cancer in Siblings of Children with Cancer in the Nordic Countries: A Population-Based Cohort Study In 2001, Winther et al. 11 In this population-based study of about 23 million people in the five Nordic countries, we aimed to assess the relations between childhood cancer and the risk of siblings, providing a powerful opportunity to evaluate the influence of recessive conditions in cancer causation. 1 Patients, Procedures and Analyses We identified all 25,605 children and adolescents with a personal identification number in whom cancer was diagnosed before they reached the age of 20, between the start of cancer registration in the five Nordic countries in the 1940s and 1950s and 31 December, 1993 (1987 in Norway).
Engl. J. , 1995, 333, 1594–1599. 10. R. H. Olsen, H. Anderson, S. Garwicz, E. Glattre, H. Hertz, F. Langmark, M. Lanning, T. Møller and H. Tulinius, N. Engl. J. , 1998, 338, 1339–1344. 11. F. Winther, R. D. , H. Tulinius, A. Bautz, L. Barlow, E. Glattre, F. Langmark, T. J. H. Olafsdottir, A. H. Olsen, Lancet, 2001, 358, 711–717. 12. M. B. Marsden, Int. J. Cancer, 1987, 40, 620–624. 13. N. Hoover, N. Engl. J. , 2000, 343, 135–136. CHAPTER 4 What Harms the Developing Male Reproductive System? 1 Introduction There has been a great deal of concern in recent years about the possibility that the health of the human male reproductive system has deteriorated over a period of some decades.
The study identified 21,665 eligible patients and 14,054 agreed to participate in the study. Of the participants, 3,162 patients reported 6,441 pregnancies and 4,157 of them were live births. Controls for the study were selected by including the siblings of the survivors and their offspring who numbered 2,339. This set of survivor offspring and sibling offspring provided an ideal situation to study the possible transgenerational effects of high-dose chemotherapy and ionizing radiation therapy. Any deviation from either the control or expected frequency of genetic disease in the survivor offspring could be evidence for germ cell mutations resulting from the cancer experience.
Male-mediated Developmental Toxicity Issues in Toxicology by Diana Anderson, Martin H. Brinkworth
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