Download PDF by Diane J. Burgess: Injectable dispersed systems: formulation, processing, and

By Diane J. Burgess

ISBN-10: 0849336996

ISBN-13: 9780849336997

This authoritative consultant will function the most up-tp-date resource at the layout and production of parenteral dispersed systems-showcasing the application of dispersed structures in drug supply, drug concentrating on, and pharmaceutical engineering.

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If this bilayer is continuous and encloses an aqueous region, then vesicles result, which are known as liposomes. Micelles are used pharmaceutically to solubilize insoluble drug substances. The drug is solubilized within the micellar core (Fig. 1). 8 Burgess Micellar solubilization allows the preparation of water-insoluble drugs within aqueous vehicles (8). v. delivery of water-insoluble drugs. Entrapment within a micellar system may increase the stability of poorly stable drug substances and can enhance drug bioavailability (9).

Burgess and Yoon (26) developed a method of assessing the relative stability of various emulsion systems, based on comparisons with initial measurements. Particle size analysis was conducted at various time intervals until the emulsion cracked. Three to five parameters were then selected (such as initial mean diameter, maximum mean diameter, time to reach maximum mean diameter, and time until phase separation was observed) and the emulsions were given a comparative score for each parameter. The highest scores were given to the apparently most stable emulsion for each parameter.

Mechanisms of instability specific to multiple emulsions (expressed for W=O=W systems) are as follows:  Coalescence of inner aqueous droplets.  Coalescence of multiple droplets.  Rupture of oil layer on the surface of the internal droplets resulting in loss of internal droplets.  Transport of water through the oil layer.  Migration of surfactant from one interface to another.

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Injectable dispersed systems: formulation, processing, and performance by Diane J. Burgess

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