Hypoxia, Metabolic Acidosis, and the Circulation by Virend K. Somers, Allyn L. Mark, François M. Abboud (auth.), PDF

By Virend K. Somers, Allyn L. Mark, François M. Abboud (auth.), Allen I. Arieff M.D. (eds.)

ISBN-10: 1461475422

ISBN-13: 9781461475422

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J. Appl. Physiol. 39: 752-758, 1975. 75. SCOTT, J. , L. J. FINKELSTEIN, and M. N. CROLL: Effects of hypoxemia on coronary blood flow and cardiac output in normal and hypothyroid dogs. Am. J. Cardiol. 10: 840-845, 1962. 76. , D. F. TEITEL, J. R. G. KUIPERS, M. A. HEYMANN, and A. M. RUDOLPH: Effect of ßadrenergic receptor blockade on responses to acute hypoxemia in lambs. Pediatr. Res. 23:229-234,1988. 77. , J. ROULEAU, L. E. BOERBOOM, and J. I. E. HOFFMAN: Myocardial blood flow and its distribution in anesthetized polycythemic dogs.

However, there is experimental evidence that increasing the oxygen affinity of hemoglobin improves tolerance to extreme altitude, and improves work Ievel at moderate altitudes. For example, Eaton et al. (12) showed that rats whose oxygen dissociation curve had been left-shifted by cyanate administration showed an increased survival when they were decompressed to a barometric pressure of 233 torr. The controls were rats with a normal oxygen affinity. Turek et al. (23) also studied cyanate-treated rats and found that they maintained better oxygen transfer to tissues during severe hypoxia than normal animals.

Both provided surprises. 5 torr (Fig. 3-1). This was a much lower value than we had predicted and underlines the extreme hyperventilation that is generated by a successful, well-acclimatized climber. The main advantage of the hyperventilation is that it helps to defend the alveolar Po2 against the extremely low value in the environmental air at this great altitude (8,848 m, 29,028 ft). A simple calculation shows that if the alveolar Pco2 were not depressed by hyperventilation, the alveolar (and therefore arterial) Po2 on the summit of Mt.

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Hypoxia, Metabolic Acidosis, and the Circulation by Virend K. Somers, Allyn L. Mark, François M. Abboud (auth.), Allen I. Arieff M.D. (eds.)

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