By H.-L. Kauppinen M.Sc., G. Myllylä M.D., K. Cantell M.D. (auth.), Warren R. Stinebring, Paul J. Chapple (eds.)
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Extra resources for Human Interferon: Production and Clinical Use
To examine the feasibility of production of relatively large amounts of human fibroblast-derived interferon, a roller bottle system has been developed using human embryo fibroblasts. Interferon induction is by treatment with the synthetic doublestranded RNA poly(I) . poly(C), and the cultures are chemically 55 56 V. G. EDY ET AL. superinduced (10-12). The cell cultures are split 1 : 2 or 1 : 4 by trypsinisation each week, and can be used for interferon production at any passage level be fore senescence; the population doubling level does not seem to affect interferon production.
Biol. Med. in press. 19. Svehag, S. , L. Leendertsen, J. R. Gorham. 1966. Sensitivity of bluetongue virus to lipid solvents, trypsin and pH changes and its serological relationship to arboviruses. J. Hyg. Camb. 64:339-346. 52 P. JAMESON AND S. E. GROSSBERG 20. K. 1974. Reproduction of reoviridae. Comprehensive Virology. Eds. H. Fraenkel-Conrat and R. R. Wagner. New York Plenum Press. pp 231-334. 21. , W. Korol, J. Yeh, et al. 1974. Detection of MasonPfizer virus infection with human KC cells carrying Rous virus genome.
I. i. = 50) Titer (units/ml) of interferon induced in replicate cultures using the indicated dose of inducer1/ Interferon Induction in HT-1376 Cells by Four Different Inducers Table 5 ~ 2 o ::IJ m "'Tl ::IJ m 2 -I o"'Tl ::IJ m ("') C o 2 r l> ::IJ < :E m 2 48 P. JAMESON AND S. E. GROSSBERG in its disaggregated form at pH 2, or predominantly 2000,000 daltons at pH 7 (J. Sedmak and S. E. Grossberg, unpublished). BTV induced leukocyte antiviral activity is relatively heat stable (63% remainin< after 2 hours at 56o C) and is neutralized by antibody to leukocyte interferon.
Human Interferon: Production and Clinical Use by H.-L. Kauppinen M.Sc., G. Myllylä M.D., K. Cantell M.D. (auth.), Warren R. Stinebring, Paul J. Chapple (eds.)