By Luigino Dal Maso, Diego Serraino, Silvia Franceschi (auth.), Joseph A. Sparano MD (eds.)
Infection with the human immunodeficiency virus (HIV) and human T-cell lymphotropic virus variety I (HTLV-I) is understood to be linked to an elevated hazard of neoplastic issues, particularly Kaposi's sarcoma and competitive B-cell lymphoma for the previous, and T-cell lymphoma for the latter. the knowledge received from the learn of those infections has resulted in striking advances in our knowing of the immune process, in addition to the biology of human neoplasms. The administration of malignant ailments in such sufferers additionally poses colossal demanding situations to clinicians. This ebook offers an outline of the epidemiology, biology, scientific positive factors, and medical administration of neoplasms happening in such members. it really is an immense source for clinicians treating those illnesses, and for uncomplicated scientists who've an curiosity during this field.
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Additional info for HIV & HTLV-I Associated Malignancies
2 Myelopathy HTLV-I-associated myelopathy (HAM) is a chronic progressive demyelinating diseasel affecting the spinal cord and white matter of the central nervous . l ' paraparesIS . (TSP) . In contrast system:l68 '269,270 . I' t IS a1so kn own as tropIca spastIc to ATL, HfLV-I infected lymphocytes in HAM are oligo- or polyclonal, rather than monoclonal. HfLV-I is believed to cause neurologic disease largely by indirect mechanisms; both an autoimmune and a cytotoxic model of pathogenesis 271 have been postulated .
There is some evidence that inhibition of the ubiquitin-proteosome degradation pathway by fulllength EBNA-l may interfere with the process by which viral peptides could be generated for MHC Class I presentation to CD8+ T cells 184. This viral encoded protein is a transactivator of the LMP-l promoter; this effect is mediated by interaction with sequence specific DNA-binding proteins known to be involved in B cell differentiation 185-187 EBNA-l expression can also induce lymphomas in transgenic mice 188.
However, the capacity for expansion is also the most error-prone feature of lymphocyte populations, because the potential for mistakes during successive rounds of gene segment recombination and mutation is high. In 23 Mechanisms for Lymphomagenesis addition, perturbations in the environment or in T cell regulatory subsets influence B-lymphocyte homeostasis. The considerable heterogeneity in the clinical and pathological features of lymphoid neoplasms therefore mirrors the heterogeneity of normal lymphocyte subpopulations interacting within a dynamic, widespread network characterized by rapid cellular responses.
HIV & HTLV-I Associated Malignancies by Luigino Dal Maso, Diego Serraino, Silvia Franceschi (auth.), Joseph A. Sparano MD (eds.)