By Y. W. Francis Lam, Shiew-Mei Huang, Stephen D. Hall
The overseas acclaim for natural treatments has lately outpaced caliber details at the usage and dosing of those compounds. This e-book fills a void within the literature by way of providing an authoritative assessment of the mechanisms of natural treatments and their impression on general drugs. It bargains a pragmatic technique that focuses not just on particular drug interactions, however the mechanisms at the back of these interactions and their medical value. With contributions from top specialists at the topic, this article examines the general use of herbs, comprises sections on person herbs, and considers pertinent regulatory concerns and issues in undefined.
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Additional info for Herbal Supplements-Drug Interactions: Scientific and Regulatory Perspectives (Drugs and the Pharmaceutical Sciences)
Prime examples of this include echinacea (78) and ginseng products (79). Gilroy analyzed different single botanical echinacea preparations purchased from retail stores and reported that only 10 of 19 preparations (53%), labeled as standardized, had an assayed content consistent with the labeled content. 28) (78). 2 mg) (79). Copyright © 2006 Taylor & Francis Group, LLC Drug Interactions with Botanical Products 41 Of particular concern is that this inconsistency in product and active constituent occurs even within the same batch.
Similarly, although administration of milk thistle 175 mg (containing 153 mg of silymarin) three times a day for three weeks resulted in 9% and 25% reduction in AUC and trough concentration, respectively, of indinavir (75,76), its differential effect on CYP3A4 and P-glycoprotein needs to be further studied. In addition, while the overall study result suggested a minimal clinical consequence for AIDS patients receiving indinavir, whether botanical constituents other than silymarin would have a greater modulating effect remains unknown.
14 days, 6 male and 6 female healthy volunteers Peppermint oil, 600 mg single dose, 9 male and 3 female healthy volunteers Effect on CYP activity 29% " in AUC of caffeine (CYP1A2)a 14% " in AUC of tolbutamide (CYP2C9)a 2% " in AUC of dextromethorphan (CYP2D6)a in EM 42% " in AUC of dextromethorphan (CYP2D6) in PM (n ¼ 1) 25% # in AUC of intravenous midazolam (CYP3A4)a 8% " in AUC of alprazolam (CYP3A4)b 26% " in urinary metabolic ratio of dextromethorphan (CYP2D6)c 40% " in AUC of felodipine (CYP3A4) a Based on geometric mean ratio of echinacea to control.
Herbal Supplements-Drug Interactions: Scientific and Regulatory Perspectives (Drugs and the Pharmaceutical Sciences) by Y. W. Francis Lam, Shiew-Mei Huang, Stephen D. Hall