By Professor Dr. med. Dr. med. h. c. Erwin Kuntz, Hans-Dieter Kuntz (auth.)
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Extra resources for Hepatology: Principles and Practice
Tab. 25) The precursory peak or shunt bilirubin (10 - 20%) is formed during the first 3 days of life from the breakdown of erythrocyte precursors in the bone marrow. A smaller proportion originates from haemoproteins in the liver. In increased erythropoiesis or in dyserythropoiesis, the proportion of precursory bilirubin is raised. 6Ilmolll] of unbound bilirubin) I upt! ke at the sinusoidal m embrane: - separat ion of albumin - binding of bilirubin to membrane transport proteins t binding and storage of bilirubin: coupled to Y proteins (= ligand in) (less frequently to Z proteins) t ,, conjugation: (di rect, water-soluble bilirubin) - monoglucuronidaLion (20-40 %) - diglucuronidation (60--80 %) intracellular transport concentration (ca.
Wschr. 1963; 105: 1-12 28. : Histochemical and immunohistochemical localization of hexokinase isoenzymes in normal rat liver. Histochem. 1. 1984; 16: 1099-1111 29. : Anatomische Varianten der Lebergebilde. Chirurg 1972; 43: 345-350 30. Loud, A. : A quantitative stereological description of the ultrastructure of normal rat liver parenchymal cells. 1. Cell BioI. 1968; 37: 27-46 31. : Anatomy of the human biliary system studied by quantitative computeraided three-dimensional imaging techniques. Hepatology 1998; 27: 893-899 32.
Deamina e 4 Porphyrin metabolism of the liver _-----------+ +. + pre-uroporphynnogen uroporphyrinogen 1 uroporphyrinogen III <, h ,« .. uroporphyrinogen III ~ynt a~e cytosol Fig. 4 flmol/kg body weight/day in the liver = ca. 10- 20% of total haem synthesis) (s. tab. 5 urine nmoU24 hr uroporphyrin coproporphyrin bica rbox yporphyri n 4 - 29 21-119 0-1 stool /lmoUg uroporphyrin coproporphyrin protoporphyrin 1-5 5-37 20-150 Tab. 3: Reference values of porphyrins and their precursors in urine and stools for differential diagnosis of porphyria References: 16, 17 I.
Hepatology: Principles and Practice by Professor Dr. med. Dr. med. h. c. Erwin Kuntz, Hans-Dieter Kuntz (auth.)