By Peter J. O'Brien, William Robert Bruce
Designed as a first-stop reference for researchers and pros in toxicology, pharmacology and medication, this guide is the first actual to tie jointly the data from many disciplines that has to this point been to be had in basic terms from greatly dispersed assets within the fundamental literature. As such, it provides the entire photograph on what's at present identified approximately endogenous pollutants, together with their iteration, mode of motion, ensuing disorder situation, and to be had countermeasures.
truly divided into 4 components, the 1st systematically covers vital poisonous molecule species, together with metabolic intermediates and reactive oxygen species. the second one discusses the position of genetically made up our minds metabolic malfunctions, comparable to galactosemia, hyperlipidemia, porphyria, hemochromatosis and similar stipulations, whereas half 3 seems to be at received and protracted illnesses brought on or exacerbated by means of endogenous pollutants, corresponding to hepatic harm, bronchial asthma, rheumatism, colorectal melanoma, reperfusion illnesses, neurodegneration and getting older. the ultimate half studies currents ideas to manage and reduce the impression of endogenous pollution, both through dietary or pharmacological interventions.
With its whole insurance integrating molecular and systemic facets from the biochemical foundation to human sickness stipulations, this complete reference will attract a extensive objective crew of toxicologists, biochemists, meals experts and physicians.Content:
Chapter 1 Endogenous DNA harm (pages 1–42): Erin G. Prestwich and Peter C. Dedon
Chapter 2 amendment of Cysteine Residues in Protein by way of Endogenous Oxidants and Electrophiles (pages 43–63): Norma Frizzell and John W. Baynes
Chapter three Endogenous Macromolecule Radicals (pages 65–101): Arno G. Siraki and Marilyn Ehrenshaft
Chapter four Alcohol?Derived Bioadducts (pages 103–132): Geoffrey M. Thiele and Lynell W. Klassen
Chapter five Iron from Meat Produces Endogenous Procarcinogenic Peroxides (pages 133–149): Denis E. Corpet, Francoise Gueeraud and Prof. Peter J. O'brien
Chapter 6 brief Chain Sugars as Endogenous pollution (pages 151–171): Ludmil T. Benov
Chapter 7 Fructose?Derived Endogenous pollution (pages 173–212): Prof. Peter J. O'Brien, Cynthia Y. Feng, Owen Lee, Q. Dong, Rhea Mehta, Jeff Bruce and Prof. W. Robert Bruce
Chapter eight Glyceraldehyde?Related response items (pages 213–225): Teruyuki Usui, Hirohito Watanabe and Fumitaka Hayase
Chapter nine Estrogens as Endogenous pollutants (pages 227–248): Jason Matthews
Chapter 10 Reactive Oxygen Species, Hypohalites, and Reactive Nitrogen Species in Liver Pathophysiology (pages 249–266): Hartmut Jaeschke
Chapter eleven Oxalate and first Hyperoxaluria (pages 267–290): Christopher J. Danpure
Chapter 12 Pathophysiology of Endogenous pollution and Their Relation to Inborn blunders of Metabolism and Drug?Mediated Toxicities (pages 291–316): Vangala Subrahmanyam
Chapter thirteen Mechanisms of Toxicity in Fatty Acid Oxidation problems (pages 317–348): J. Daniel Sharer
Chapter 14 Homocysteine as an Endogenous Toxin in heart problems (pages 349–378): Sana Basseri, Jennifer Caldwell, Shantanu Sengupta, Arun Kumar and Richard C. Austin
Chapter 15 Uric Acid adjustments in Cardiometabolic problems and Gout (pages 379–394): Renato Ippolito, Ferruccio Galletti and Pasquale Strazzullo
Chapter sixteen Genetic Defects in Iron and Copper Trafficking (pages 395–418): Douglas M. Templeton
Chapter 17 Polyglutamine Neuropathies: Animal versions to Molecular Mechanisms (pages 419–447): Kelvin Hui and Jeffrey Henderson
Chapter 18 Alcohol?Induced Hepatic harm (pages 449–483): Emanuele Albano
Chapter 19 Ethanol?Induced Endotoxemia and Tissue damage (pages 485–509): Radhakrishna ok. Rao
Chapter 20 intestine Microbiota, vitamin, Endotoxemia, and illnesses (pages 511–524): Patrice D. Cani and Nathalie M. Delzenne
Chapter 21 Nutrient?Derived Endogenous pollutants within the Pathogenesis of variety 2 Diabetes on the ??Cell point (pages 525–555): Christine Tang, Andrei I. Oprescu and Adria Giacca
Chapter 22 Endogenous pollution and Susceptibility or Resistance to Diabetic issues (pages 557–576): Paul J. Beisswenger
Chapter 23 Serum complex Glycation finish items linked to NASH and different Liver illnesses (pages 577–593): Hideyuki Hyogo, Sho?ichi Yamagishi and Susumu Tazuma
Chapter 24 Oxidative rigidity within the Pathogenesis of Hepatitis C (pages 595–617): Tom S. Chan and Marc Bilodeau
Chapter 25 Oxidized Low Density Lipoprotein Cytotoxicity and Vascular affliction (pages 619–645): Steven P. Gieseg, Elizabeth Crone and Zunika Amit
Chapter 26 Oxidative tension in Breast melanoma Carcinogenesis (pages 647–672): Lisa J. Martin and Norman Boyd
Chapter 27 way of life, Endogenous pollution, and Colorectal melanoma danger (pages 673–693): Gail McKeown?Eyssen, Jeff Bruce, Owen Lee, Prof. Peter J. O'Brien and Prof. W. Robert Bruce
Chapter 28 Dopamine?Derived Neurotoxicity and Parkinson's sickness (pages 695–714): Jose Luis Labandeira?Garcia
Chapter 29 Dopamine Catabolism and Parkinson's disorder: function of a Reactive Aldehyde Intermediate (pages 715–731): Jonathan A. Doorn
Chapter 30 Tetrahydropapaveroline, an Endogenous Dicatechol Isoquinoline Neurotoxin (pages 733–746): Young?Joon Surh and Hyun?Jung Kim
Chapter 31 Chemically caused Autoimmunity (pages 747–768): Michael Schiraldi and Marc Monestier
Chapter 32 Endogenous pollutants linked to lifestyles Expectancy and getting older (pages 769–786): Victoria Ayala, Jordi Boada, Jose Serrano, Manuel Portero?Otin and Reinald Pamplona
Chapter 33 healing strength for lowering the Endogenous Toxin Homocysteine: scientific Trials (pages 787–839): Wolfgang Herrmann and Rima Obeid
Chapter 34 Prevention of Oxidative Stress–Induced ailments by means of common nutritional Compounds: The Mechanism of activities (pages 841–857): Tin Oo Khor, Ka?Lung Cheung, Avantika Barve, Harold L. Newmark and Ah?Ng Tony Kong
Chapter 35 Genotoxicity of Endogenous Estrogens (pages 859–879): James S. Wright
Chapter 36 layout of dietary Interventions for the regulate of mobile Oxidation (pages 881–906): Elizabeth P. Ryan and Henry J. Thompson
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Extra resources for Endogenous Toxins: Targets for Disease Treatment and Prevention
A further understanding of the work of others in the ﬁeld would identify overlapping interests that could be exploited by any one of us. Such a volume could thus be helpful to epidemiologists, by identifying new hypotheses relating lifestyle factors with endogenous toxins and chronic disease; helpful to chemists and biochemists, by identifying likely important areas of investigation; and helpful to investigators in all disciplines, by providing a broader perspective of the problem and approaches taken by others in this complex ﬁeld.
These chemistries can damage both nucleobases and the sugar–phosphate backbone of DNA through oxidation, halogenation, nitration, alkylation, and deamination, which can lead to mutation and cancer directly or by cytotoxicity-induced cell turnover. This chapter thus focuses on recent studies of the sources and products of DNA and RNA damage caused by endogenous processes, with an emphasis on adducts not addressed in other review articles, and on oxidative stress and inﬂammation. 1 Introduction The past several decades have witnessed a major shift in thinking about pathological damage to cellular molecules, particularly DNA, with a growing appreciation for endogenous processes in addition to exogenous sources.
74 V vs. 2). This relative instability demands great care to avoid artifacts of oxidation during DNA isolation and processing steps involved in the quantiﬁcation of 8-oxo-G. Further, the ready oxidation of 8-oxo-G suggests that the other more stable G oxidation products would serve as more abundant and possibly better biomarkers of DNA oxidation. As opposed to the predominance of G•+ as the initial product of one-electron oxidation of G, hydroxyl radical reacts with DNA bases mainly by nucleophilic attack, with formation of 8-OH-G• and 4-OH-G• radicals in the case of G.
Endogenous Toxins: Targets for Disease Treatment and Prevention by Peter J. O'Brien, William Robert Bruce