By U.A. Meyer, Jean-Michel Metry, Urs B. Meyer
This important paintings comprehensively covers all problems with drug routine compliance. In 3 sections--Clinical Trials, sufferer administration, and destiny Aspects--it bargains with a subject matter of dialogue and curiosity.
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Am Heart J 104: 473–8, 1982. 41. Psaty BM, Koepsell TD, Wagner EH, LoGerfo JP, Inui TS. The relative risk of incident coronary heart disease associated with recently stopping the use of beta blockers. JAMA 263:1653–7, 1990. 42. Houston MC, Hodge R. Beta-adrenergic blocker withdrawal syndromes in hypertension and other cardiovascular diseases. Am Heart J 116: 515–23, 1988. SEQ 0057 JOB PDF8222-002-003 PAGE-0023 CHAP 2 23-40 REVISED 05DEC01 AT 11:59 BY TF DEPTH: 58 PICAS WIDTH 40 PICAS Drug Regimen Compliance: Issues in Clinical Trials and Patient Management Edited by Jean-Michel M´etry and Urs A.
G. causality, incidence). Indexing Compliance Data The first problem to be solved is how to aggregate the repeated measurements of compliance10,18. Compliance can be calculated as the number of days at which all prescribed doses have been administered divided by the number of days of the treatment period, or as the number of doses actually administered divided by the number of all doses prescribed. If reliable data for the duration of drug action are available the time intervals between drug administrations can be used to calculate an index called ‘timing compliance’.
Efron and Feldmann have reanalyzed the Lipid Research Clinics Coronary Primary Prevention Trial (LRC-CPPT) data with the aim of extracting an unbiased compliance–response relationship20. Rubin’s key idea was to obtain a p value using a posterior predictive check distribution, which includes a model for non-compliance behavior, although only under the sharp null hypothesis of ‘no effect of assignment or receipt of treatment on outcome’21. Goetghebeur has used and compared several techniques for a variety of trials22,23, some with compliance data of questionable quality and focusing on physician-initiated changes of treatment24, a topic not covered by the definition of patient compliance given in this chapter.
Drug Regimen Compliance by U.A. Meyer, Jean-Michel Metry, Urs B. Meyer