By Curtis D. Klaassen, John B. Watkins III
The so much concise and authoritative creation to the rules of toxicology and the way poisons have an effect on the human physique – now in complete color
Casarett & Doull's necessities of Toxicology is an easy-to-absorb distillation of the field's gold-standard textual content Casarett & Doull's Toxicology: the fundamental technology of Poisons. provided in complete colour for the 1st time, the e-book combines an available and fascinating process with insurance of crucial introductory ideas to supply you with an effective grounding in simple and clinical toxicology. Succinct, but accomplished, the textual content covers crucial rules, toxicokinetics, how poisonous results are handed directly to succeeding generations, how every one physique method responds to poisons, and the explicit results of quite a lot of poisonous brokers – from insecticides to radiation.
• an entire easy assessment of toxins and their scientific management
• displays the services of greater than fifty popular contributors
• A precis of significant issues is integrated at the start of every bankruptcy and multiple-choice evaluate questions look on the conclusion
• very important chapters on leading edge themes corresponding to Analytic/Forensic Toxicology, scientific Toxicology, Occupational Toxicology, pollution, and Ecotoxicology
Condensed desk of Contents: normal ideas of Toxicology, Disposition of Toxicants, Nonorgan-Directed Toxicity, objective Organ Toxicity, poisonous brokers, Environmental Toxicology, functions of Toxicology.
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Additional resources for Casarett & Doull's Essentials of Toxicology (2nd Edition)
Elias SG, van Noord PA, Peeters PH et al. Childhood exposure to the 1944–1945 Dutch famine and subsequent female reproductive function. Hum Reprod 2005; 20: 2483–8. Fisher JS. Environmental anti-androgens and male reproductive health: focus on phthalates and testicular dysgenesis syndrome. Reproduction 2004; 127: 305–15. Friedman JM. Implications of research in male-mediated developmental toxicity to clinical counsellors, regulators, and occupational safety officers. Adv Exp Med Biol 2003; 518: 219–26.
Principle 2 Not all mammalian species are equally susceptible or sensitive to the reproductive toxic influence of a given chemical. The inter- and intraspecies variability may be manifested in several ways: a drug that acts in one species may have little or no effects in others; a reproductive toxicant may produce similar defects in various species, but these defects will vary in frequency; a substance may induce certain developmental disorders in one species that are entirely different from those induced in others.
The FDA classification as published in the Federal Register (2000) is not much different from the earlier one indicated in the previous edition of this book as being under “reconstruction”. In the EU, a specification of the medicinal products to be used in pregnancy has to be given on the summary of product characteristics, including: ■ ■ ■ 1 facts regarding human experience and conclusions from preclinical toxicity studies which are of relevance for the assessment of risks associated with exposure during pregnancy recommendations on the use of the medicinal product at different times during pregnancy in respect of gestation recommendations on the management of the situation of an inadvertent exposure, where relevant.
Casarett & Doull's Essentials of Toxicology (2nd Edition) by Curtis D. Klaassen, John B. Watkins III