By John D. McConnell (auth.), Reginald C. Bruskewitz MD (eds.)
ISBN-10: 1461565057
ISBN-13: 9781461565055
ISBN-10: 1461565073
ISBN-13: 9781461565079
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Extra resources for Atlas of the Prostate
Sample text
To date, no clinical benefit has been demonstrated in prostate cancer patients treated with finasteride. { 0 Vl c... 3 « 40 20 O ~----~~-----r------~----~----~ 24 12 18 o 6 Tim ,rna t FIGURE 3-14. Adverse effects of hormonal therapy. The most deleterious effects of agents that alter the hypothalamic-gonadal axis at different levels along the pathway are related to varying degrees of sexual dysfunction. Interventions that markedly lower serum testosterone levels are associated with greater degrees of sexual dysfunction (eg, loss oflibido) than are agents that block the effect of testosterone on target organs [47].
Xl d-aor nor ptor eptor t FIGURE 3-16. Distribution of a-adrenoreceptor subtypes in the lower urinary tract [54]. ala-Receptors predominate in the prostatic epithelial tissue, bladder trigone, and the urethra. aId-Receptors predominate in the bladder. ala-Receptors also predominate in the prostatic vascular smooth muscle. However, with aging alb-receptors are expressed and ultimately predominate. This transition occurs around age 50 years. T hus blockade of ala-receptors is believed to improve obstructive symptoms by decreasing the prostatic obstruction, while blockade of a I d-receptors is believed to relieve irritative symptoms by reducing bladder tone.
Xl d-aor nor ptor eptor t FIGURE 3-16. Distribution of a-adrenoreceptor subtypes in the lower urinary tract [54]. ala-Receptors predominate in the prostatic epithelial tissue, bladder trigone, and the urethra. aId-Receptors predominate in the bladder. ala-Receptors also predominate in the prostatic vascular smooth muscle. However, with aging alb-receptors are expressed and ultimately predominate. This transition occurs around age 50 years. T hus blockade of ala-receptors is believed to improve obstructive symptoms by decreasing the prostatic obstruction, while blockade of a I d-receptors is believed to relieve irritative symptoms by reducing bladder tone.
Atlas of the Prostate by John D. McConnell (auth.), Reginald C. Bruskewitz MD (eds.)
by John
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