Download e-book for kindle: Antiandrogens in Prostate Cancer: A Key to Tailored by Louis Denis (auth.), Professor Dr. Louis Denis (eds.)

By Louis Denis (auth.), Professor Dr. Louis Denis (eds.)

ISBN-10: 3642457452

ISBN-13: 9783642457456

ISBN-10: 3642457479

ISBN-13: 9783642457470

The advent of maximal androgen blockade as a scientific treatment through Brachi and Labrie greater than a decade in the past ended in a massive controversy at the medical use of antiandrogens within the therapy of prostate melanoma. 3 consensus conferences have been for this reason equipped with the help of the yank melanoma Society, the Urological team of the ecu association for examine and therapy of melanoma and the foreign Prostate health and wellbeing Council. the 1st result of the meta-analysis of twenty-two trials didn't positioned an finish to the debate, despite the fact that, and clinicians have been left careworn by way of conflicting studies released by means of dozens of specialists. The assembly at the back of the current quantity created a discussion board for the scientists who constructed the medicine and professional clinicians to provide a consensus. the result's an summary of the sector, condensed from enormous quantities of courses. the knowledge has been up to date to supply distinct medical symptoms for using antiandrogens together remedies and monotherapy for the person sufferer. we are hoping that this workforce attempt will facilitate ongoing discussions and bring about better sufferer care in addition to elevated wisdom of the medicine which are so very important to our sufferers' caliber of existence and survival.

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Additional resources for Antiandrogens in Prostate Cancer: A Key to Tailored Endocrine Treatment

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Am J Clin Oncol 1988 (11 Suppl): S1-S7 Logan A and Hill DJ: Bioavailability: Is this a key event in regulating the actions of peptide growth factors? J Endocrinol1992 (134):157-161 Cohen P, Peehl DM, Rosenfield RG. In: Proceedings of the International Symposium on Biology of Prostate Growth. Bethesda 1992 (in press) Martinoli MG and Pelletier G: Dihydrotestosterone (DHT) regulation of insulin-like growth factor II mRNA in neonatal rats. Peptides 1991 (12):12671271 Cohen P, Peehl DM, Lamson G, Rosenfield RG: Insulin-like growth factors (IGFs), IGF receptors, and IGF-binding proteins in primary cultures of prostate epithelial cells.

Approximately 30% of the metabolites are eliminated with the urine and 70% with the bile. The terminal half-life is about 30 to 40 hours. CPA does not accumulate. An equilibrium between administration and excretion is established after 8 to 10 days' use. With a half-life of almost 2 days a highly constant concentration is achieved in target tissues for androgens (and antiandrogens). The administration of the depot (300 mg/ampoule) leads after 2 to 3 days to maximal substance levels of about 300 to 400 ng/ml with a half-life of 4 days.

As a quite potent progestogen (see later), CPA does also inhibit the occurrence of hot flushes after orchidectomy or under treatment with LHRH analogues [30,31]. [26]. It has been argued that, in sufficiently high concentrations, pure antiandrogens should be able to completely antagonise the effect of even high amounts of androgens at the receptor level [27]. That this is not the case has been shown in animal studies (Fig. 5). In contrast to the effect of CPA it is not possible, even with high doses of flutamide, to inhibit prostate weights of intact rats completely.

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Antiandrogens in Prostate Cancer: A Key to Tailored Endocrine Treatment by Louis Denis (auth.), Professor Dr. Louis Denis (eds.)

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