By Edward D. Levin, Jerry J. Buccafusco
ISBN-10: 0849328349
ISBN-13: 9780849328343
The prices linked to a drug’s scientific trials are so major that it has turn into essential to validate either its defense and efficacy in animal versions sooner than the continuing research of the drug in people.
Featuring contributions from wonderful researchers within the box of cognitive remedy learn, Animal versions of Cognitive Impairment examines one of the most well known and profitable animal archetypes utilized in the context of drug discovery. It offers built-in assurance of the newest examine relating neuronal structures correct to cognitive functionality and disorder, assimilating reports of this learn in the context of every bankruptcy. This process is exclusive in that it brings jointly molecular and neurochemical methodologies, behavioral functions in translational types, and medical functions.
The publication comprehensively discusses a wide selection of animal versions of cognitive impairment, together with genetic, lesion, pharmacological, and getting older similar impairments. It additionally explores the importance of this examine about the remedy of varied addictions and problems corresponding to stroke, autism, Alzheimer’s, schizophrenia, and ADHD.
Edited by way of popular specialists within the box, Animal types of Cognitive Impairment is a well timed ebook that gives built-in assurance of state of the art learn that matters neuronal structures correct to cognitive functionality and disorder.
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Extra resources for Animal Models of Cognitive Impairment
Sample text
It also seems to affect working memory and not reference memory [34, 40]. Mecamylamine had varying effects in aged rats, depending on the task given. It was ineffective in aged rats on the RAM [32] but exacerbated the effects on the 5-CRSTT [20]. REFERENCES 1. ), 115, 485–494, 1994. 2. , Effects of various drugs including organophosphorus compounds (OPC) and therapeutic compounds against OPC on DRL responding, Pharmacol. Biochem. , 59, 1069–1080, 1998. 3. , Deficits in passive avoidance learning in young rats following mecamylamine injections in the hippocampo-entorhinal area, Exp.
Gen. Psychiatry, 44, 418–426, 1987. fm Page 15 Tuesday, May 30, 2006 12:28 PM Muscarinic Receptor Antagonists in Rats 15 13. , Chronic nimodipine treatment in aged rats: analysis of motor and cognitive effects and muscarinic-induced striatal dopamine release, Neurobiol. Aging, 15, 55–61, 1994. 14. Kubanis, P. , Age-related behavioral and neurobiological changes: a review with an emphasis on memory, Behav. , 31, 115–172, 1981. 15. , 434, 423–438, 1987. 16. Gallagher, M. , Ageing: the cholinergic hypothesis of cognitive decline, Curr.
Pharmacological studies of a rat spatial delayed nonmatch-to-sample task as an animal model of dementia, Drug Dev. , 24, 67–79, 1991. 12. W. ), 107, 530–534, 1992. 13. , Effects of lobeline, a nicotinic receptor agonist, on learning and memory, Pharmacol. Biochem. , 45, 571–576, 1993. 14. , Effects of ABT-418, a novel cholinergic channel ligand, on place learning in septal-lesioned rats, Eur. J. , 261, 217–222, 1994. 15. , 56, 545–570, 1995. 16. Elrod, K. , Correlation of the amnestic effects of nicotinic antagonists with inhibition of regional brain acetylcholine synthesis in rats, J.
Animal Models of Cognitive Impairment by Edward D. Levin, Jerry J. Buccafusco
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