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D. Rainsford, ed. London and New York: Taylor & Francis, 2004d, 707–756. Rainsford KD. Inhibitors of eicosanoids. In: The Eicosanoids, P Curtis-Prior, ed. Chichester: John Wiley & Sons, 2004e, 189–210. Rainsford KD. Occurrence, properties and synthetic developments of the salicylates. D. Rainsford, ed. London & New York: Taylor & Francis, 2004f, 45–95. Rainsford KD. Aspirin and NSAIDs in the prevention of cancer, Alzheimer’s disease and other novel therapeutic actions. D. Rainsford, ed. London & New York: Taylor & Francis, 2004g, 707–756.
G. see Rainsford, 1999; 2004f) some of which have passed out of fashion, but these may have utility in some conditions where their mechanism of action suits the particular application. There are also the new signal transduction inhibitors that may have specific utility in a wide variety of inflammatory conditions by virtue of their mechanism of action. Anti-cytokine agents may eventually prove to be useful for chronic diseases not only by way of therapeutic benefits and targets for their actions, but also by way of showing “proof of principle” which can serve to encourage development of small molecules to control the action of target cytokines either at the level of cytokine receptors or post-receptor signalling events.
The meniscus was originally believed to be a useless structure, but we now know that it is a critical component of the function of the knee joint. In the past, menisci have been primarily considered as anatomic structures that provide these mechanical functions. However, our recent work documents that the fibrochondrocyte cells in the menisci play an important role in modulating the biochemical environment of the knee joint through the synthesis and release of cytokines and inflammatory mediators such as PGE2 , NO, TNF, IL-1, and IFN- .
AHA ACLS STROKE GUIDELINES 2010 by AHA
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