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By Lauren M.F. Merlo, Li-san Wang, John W. Pepper (auth.), Randy Y. C. Poon MA, PhD (eds.)

ISBN-10: 1441961984

ISBN-13: 9781441961983

Limiting genome replication to as soon as in step with cellphone cycle is key for conserving genome balance. even though polyploidization is of physiologically value for numerous really good cellphone varieties, beside the point polyploidization is assumed to advertise aneuploidy and transformation. A growing to be physique of facts shows that the surveillance mechanisms that hinder polyploidization are usually perturbed in cancers. development long ago a number of years has unraveled the various underlying rules that continue genome balance. This e-book brings jointly leaders of the sector to review matters on the subject of polyploidization and cancer.

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5. Kapoor TM, Lampson MA, Hergert P et al. Chromosomes can congress to the metaphase plate before biorientation. Science 2006; 311:388-391. 6. Cleveland DW, Mao YH, Sullivan KF. Centromeres and kinetochores: From epigenetics to mitotic checkpoint signaling. Cell 2003; 112:407-421. 7. Hwang LH, Lau LF, Smith DL et al. Budding yeast Cdc20: a target of the spindle checkpoint. Science 1998; 279:1041-1044. 8. Kim SH, Lin DP, Matsumoto S et al. Fission yeast Slp1: An effector of the Mad2-dependent spindle checkpoint.

16 Polyploidization and Cancer Bipolar Attachment and Chromosome Congression Chromosomes, which are distributed randomly in the nucleus at the onset of mitosis, must be placed on the metaphase plate before anaphase. , they attach to the spindle via two kinetochores, each of which interacts with the spindle radiated from one of the two poles) and are positioned on the spindle equator (Fig. 1), a mid point between the two poles. Interaction between the spindle and chromosomes plays a key role in determining the position of each chromosome in mitosis.

Thus, the spindle checkpoint can be Molecular Mechanisms and Function of the Spindle Checkpoint 25 referred to as a guardian of chromosome stability and a barrier of tumor development/progression. Although spindle poisons such as taxol and nocodazole may be considered as effective anticancer drugs, the cellular effect of these drugs should be reexamined. In the presence of a spindle poison, cells lacking the spindle checkpoint would escape mitosis without separating sister chromatids and become polyploids, some of which could grow more aggressively.

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Polyploidization and Cancer by Lauren M.F. Merlo, Li-san Wang, John W. Pepper (auth.), Randy Y. C. Poon MA, PhD (eds.)

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